CYP3A4 Inhibitors Isolated from Licorice(Pharmacognosy)
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概要
- 論文の詳細を見る
The extract of licorice (Glycyrrhiza uralensis FISHER, Leguminosae) showed CYP3A4 inhibitory activity with the IC_<50> value of 0.022mg/ml. Bioassay-guided purification afforded nine compounds, 3-(p-hydroxyphenyl)propionic acid (1), isoliquiritigenin (2), (3R)-vestitol (3), licopyranocoumarin (4), 4-hydroxyguaiacol apioglucoside (5), liquiritin (6), liquiritigenin 7, 4'-diglucoside (7), liquiritin apioside (8), and glucoliquiritin apioside (9). Among these compounds, 3, 7, and 5 showed potent CYP3A4 inhibitory activities with IC_<50> values of 3.6, 17, and 20μM, respectively. Glycyrrhizin (10), a main constituent of licorice, however, was inactive for CYP3A4 inhibition.
- 公益社団法人日本薬学会の論文
- 2005-10-01
著者
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Tsukamoto Sachiko
Graduate School of Pharmaceutical Sciences, Kumamoto University
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Yamashita Yuko
Graduate School Of Natural Science And Technology Kanazawa University
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Ohta Tomihisa
金沢大学 大学院自然科学研究科
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Ohta Tomihisa
Graduate School Of Natural Science And Technology Kanazawa University
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ABURATANI Maki
Graduate School of Natural Science and Technology, Kanazawa University
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YOSHIDA Tomohiro
Graduate School of Natural Science and Technology, Kanazawa University
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EL BEIH
Graduate School of Natural Science and Technology, Kanazawa University
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El Beih
Graduate School Of Natural Science And Technology Kanazawa University
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Aburatani Maki
Graduate School Of Natural Science And Technology Kanazawa University
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Sachiko Tsukamoto
Graduate School Of Natural Science And Technology Kanazawa University
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Tsukamoto Sachiko
Graduate School Of Natural Science And Technology Kanazawa University
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Yoshida Tomohiro
Graduate School Of Bioagricultural Sciences Nagoya University
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Yoshida Tomohiro
Graduate School Of Natural Science And Technology Kanazawa University
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