Thyrotoxic Myopathy Mimicking Myasthenic Syndrome Associated with Thymic Hyperplasia
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概要
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A 41-year-old man with progressive limb weakness manifested fluctuating muscle weakness as seen in myasthenia gravis (MG). Laboratory investigations revealed hyperthyroidism without the complication of MG. Electrophysiological studies demonstrated abnormal features of neuromuscular transmissions resembling those of the Lambert-Eaton myasthenic syndrome rather than those of MG. A CT scan showed a mediastinal mass that suggested thymic hyperplasia which often complicates MG or hyperthyroidism. Medical treatment of hyperthyroidism resulted in resolution of MG-like symptoms and regression of thymic hyperplasia on CT concomitant with normalization of thyroid function. This case highlights the fact that careful investigations are needed to differentiate MG-like symptoms from genuine MG in cases of hyperthyroidism with thymic lesions.
著者
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Shimohama Shun
Department of Neurology, Sapporo Medical University School of Medicine
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Tsuda Emiko
Department Of Neurology Sapporo Medical University School Of Medicine
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Nonaka Michio
Department Of Food Science & Technology Faculty Of Agriculture Kyushu University
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Hisahara Shin
Department Of Neuroanatomy Biomedical Research Center Osaka University Medical School
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Imai Tomihiro
Department Of Neurology Sapporo Medical University School Of Medicine
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Shimohama Shun
Department Of Neurology Faculty Of Medicine Kyoto University
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Matsumura Akihiro
Department of Frontier Materials, Nagoya Institute of Technology, Nagoya 466-8555, Japan
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Motomura Masakatsu
The First Department of Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
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Nonaka Michio
Department of Neurology, Sapporo Medical University School of Medicine
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Shiraishi Hirokazu
The First Department of Internal Medicine, Graduate School of Biomedical Science, Nagasaki University
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Motomura Masakatsu
The First Department of Internal Medicine, Graduate School of Biomedical Science, Nagasaki University
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