Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions : NAD-Dependent Histone Deacetylase SIRT1 (Sir2α)
スポンサーリンク
概要
- 論文の詳細を見る
Sir2 (silent information regulator 2) is an NAD-dependent deacetylase that is broadly conserved from bacteria to humans. It catalyzes a unique deacetylation reaction using NAD, and specific inhibitors and activators of its activity have been discovered. In yeast, Sir2 deacetylates histones and participates in transcription silencing and the suppression of recombination. Sir2 is also implicated in the regulation of aging, because its increased expression extends the lifespan of yeast and nematodes. Mammalian SIRT1 (Sir2α) is a member of the Sir2 family. Recently, SIRT1 was shown to interact with various transcription factors such as p53, forkhead transcription factor (FOXO) family proteins, and MyoD, and to participate in stress tolerance, differentiation, and development.
- 社団法人 日本薬理学会の論文
- 2005-07-20
著者
-
Hisahara Shin
Department of Neurology, Sapporo Medical University School of Medicine
-
Matsumoto Hiroyuki
Department of Electrical Engineering, Toyo University
-
Horio Yoshiyuki
Department of Pharmacology, Sapporo Medical University
-
Hisahara Shin
Department Of Neuroanatomy Biomedical Research Center Osaka University Medical School
-
Hisahara Shin
Department Of Pharmacology Sapporo Medical University School Of Medicine
-
CHIBA Susumu
Department of Neurology School of Medicine, Sapporo Medical University
-
Chiba Susumu
Department Of Neurology Sapporo Medical University School Of Medicine
-
Chiba Susumu
Department Of Aquatic Bioscience Tokyo University Of Agriculture
-
Horio Yoshiyuki
Department Of Pharmacology Sapporo Medical University School Of Medicine
-
Horio Yoshiyuki
Department Of Pharmacology Ii Faculty Of Medicine Osaka University
-
Matsumoto Hiroyuki
Department Of Biochemistry And Molecular Biology University Of Oklahoma Health Sciences Center
-
Matsumoto Hiroyuki
Department Of Neurology Sapporo Medical University School Of Medicine
-
Matsumoto Hiroyuki
Department Of Biochemistry And Molecular Biology The University Of Oklahoma Health Sciences Center
-
HORIO Yoshiyuki
Department of Pharmacology, Sapporo Medical University, School of Medicine
-
Chiba Susumu
Department of Neurology, Sapporo Medical University, School of Medicine
関連論文
- Response of Serum Carboxylated and Undercarboxylated Osteocalcin to Risedronate Monotherapy and Combined Therapy with Vitamin K2 in Corticosteroid-Treated Patients: A Pilot Study
- Measurement of Fluorocarbon Radicals Generated from C_4F_8/H_2 Inductively Coupled Plasma : Study on SiO_2 Selective Etching Kinetics
- OJ-103 Role of Intra-mitochondrial GSK-3β in Bax Regulation And Antiapoptotic Resistance of Cardiomyocytes(Cell death, apoptosis/necrosis(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-545 Distinct Roles of FOXO Subtypes in SIRT1-mediated Mn-SOD Up-regulation under Oxidative Stress(PE091,Molecular Biology (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- DPE-012 Activation of SIRT1, a Histone/Protein Deacetylase, by Resveratrol Up-regulates MnSOD and Suppresses the Progression of Heart Failure(DPE02,Heart Failure, Basic (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanes
- PE-333 Resveratrol, An Activator of Longevity Protein SIRT1, Suppresses Progression of Heart Failure Through SIRT1-mediated Cardiomyocyte Protection Against Oxidant Stress(Heart failure, basic(03)(M),Poster Session(English),The 72nd Annual Scientific Meet
- PE-443 Role of Glycogen Synthase Kinase-3 β in Cardiomyocyte Protection by Erythropoietin(Heart failure, basic-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-312 Nuclear Localization of SIRT1, a Novel Mechanism of Cardiomyocyte Protection in Failing Hearts, is Achieved by PI3K/Akt Signaling(Heart failure, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-601 Molecular Mechanisms of Nucleo-cytoplasmic Shuttling of SIRT1, a Histone Deacetylase, and Its Pathopysicological Roles in Cardiomyocytes(Molecular biology, myocardium-2 (M) PE106,Poster Session (English),The 70th Anniversary Annual Scientific Meeti
- Advanced Hirayama Disease with Successful Improvement of Activities of Daily Living by Operative Reconstruction
- Protein Carbonylation Detected with Light and Heavy Isotope-Labeled 2,4-Dinitrophenylhydrazine by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
- Transport of Human Immunoglobulin G and Fc-Fusion Proteins to Chicken Egg Yolk(BIOCHEMICAL ENGINEERING)
- Production of Anti-CD2 Chimeric Antibody by Recombinant Animal Cells(CELL AND TISSUE ENGINEERING)
- Production of Anti-Prion scFv-Fc Fusion Proteins by Recombinant Animal Cells
- Growth of YBa_2Cu_3O_ Superconducting Thin Films on [111] Oriented Ag Films
- Affinity-Tagged Phosphorylation Assay by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (ATPA-MALDI) : Application to Calcium/Calmodulin-Dependent Protein Kinase
- P-136 A New Practical Proteomic Method for Quantitative Analysis of Proteins Using Stable Isotope-labeling Small Organic Molecules
- Crow-Fukase Syndrome with Ischemic Cardiomyopathy
- Load and Strain Histories for CFRP Laminates under Low-Velocity Impact
- Cloning and Characterization of Homolog of Sir2, a Regulator of Yeast Life Span and Senescence, in the Mouse
- Ion channels and diseases
- A review of ecological and evolutionary studies on hermaphroditic decapod crustaceans
- Inwardly Rectifying K^+ Channel in Retinal Muller Cells : Comparison with the K_-2/Kir4.1 Channel Expressed in HEK293T Cells
- Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions : NAD-Dependent Histone Deacetylase SIRT1 (Sir2α)
- Lhermitte's Sign in Alcoholic Myelopathy without Portosystemic Shunting : MRI Evaluation
- IS056 Identification of Critical Amino Acid Residues in the Extracellular Linker Region Responsible for the Difference in the Unitary Conductance of SUR/Kir6.0 Complex Channels
- Detection of Serum Antibody against Arrestin from Patients with Acute Disseminated Encephalomyelitis
- Measurement of Anisotropic Elastic Moduli in Local Area by Acoustic Microscope : The Case of Cubic Single Crystal
- Elastodynamic Thin Plate Bending Analysis by Boundary Element Method with Laplace Transform
- Effects of Couplers on Acoustic Velocity Measurement by Complex V(z) Method
- Correlation between the M and F wave characteristics and the innervated muscle strength in spinal muscular atrophy
- Molecular Aspects of ATP-Sensitive K^+ Channels in the Cardiovascular System
- Myositis Ossificans of the Temporal Muscle as a Primary Scalp Tumor : Case Report
- The Impact Stresses Produced in a Suspended Cylindrical Bar Due to a Longitudinal Tensile Impact (the Journal and the Transactions of the Japan Society of Mechanical Engineers)
- Caspase-mediated oligodendrocyte cell death in the pathogenesis of autoimmune demyelination
- INVOLVEMENT OF CASPASES IN TNFα-MEDIATED OLIGODENDROCYTES CELL DEATH
- Presence of Associated Exonuclease in DNA Polymerase-B from Cauliflower Inflorescence
- カリフラワ-DNAポリメラ-ゼの分離とその性質〔英文〕
- Preservation of central motor conduction in patients with spinal muscular atrophy typeII
- Stresses in a Circular Cylinder Having an Eccentric Spherical Cavity under Tension
- Potassium Channels of Glial Cells: Distribution and Function
- Analysis of the Dynamic Stress Concentration Factor by the Two-Dimensional Boundary Element Method
- Reproductive Cycle of the Protandric Shrimp Pandalus latirostris in Saroma Lagoon
- The short time asymptotics of the traces of the heat kernels for the magnetic Schrödinger operators
- Thyrotoxic Myopathy Mimicking Myasthenic Syndrome Associated with Thymic Hyperplasia
- On the integrated density of states for the Schrodinger operators with certain random electromagnetic potentials
- A Case of In-Stent Neoatherosclerosis 10 Years after Carotid Artery Stent Implantation: Observation with Optical Coherence Tomography and Plaque Histological Findings