Effects of Betamipron on Cisplatin Nephrotoxicity and Its Pharmacokinetics in Rats
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概要
- 論文の詳細を見る
The protective effects of betamipron (BP, N-benzoyl-β-alanine) on the nephrotoxicity of cisplatin were examined as indicated by body weight gain, ratio of kidney weight to body weight, blood urea nitrogen and serum creatinine levels in tumor-bearing rats. The results showed clearly that administration of BP 1h after cisplatin treatment affords protection against the nephrotoxicity of cisplatin. Furthermore, the addition of BP to cisplatin had no apparent effect on the efficacy of cisplatin against Walker 256 carcinosarcoma cells in rats. In addition, no observed significant difference in plasma cisplatin concentration between cisplatin with alkaline solution and cisplatin with BP may be partly attributed to the decrease in the cisplatin exsorption to the intestine and its excretion to bile, and to an increase in cisplatin excretion to the urine.
- 公益社団法人日本薬学会の論文
- 1997-04-15
著者
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KITAGAWA Akira
Department of Clinical Trial Management, Graduate School, International University of Health and Wel
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NAKANO Masahiro
Department of Physics, Kyoto University
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Nakano M
Department Of Information Science University Of Occupational And Environmental Health
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TOKUNAGA Jin
Department Pharmacy, Kumamoto University Hospital
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NAKAMURA Chizuko
Department of Pharmacy, Kumamoto University Hospital
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ARIMORI Kazuhiko
Department of Pharmacy, Miyazaki Medical College Hospital
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KOBAYASHI Mie
Department of Pharmaceutical Services, Kumamoto University Hospital
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Nakano M
University Of Occupational And Environmental Health
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Nakano M
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Nakano Masahiro
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Kobayashi M
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Josai University
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Kobayashi Mie
Department Of Pediatric Dentistry Osaka Dental University
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Kitagawa Akira
Department Of Clinical Trial Management Graduate School International University Of Health And Welfa
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Kitagawa Akira
Department Of Pharmaceutical Services Kumamoto University Hospital
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Nakano M
Univ. Occupational And Environmental Health Jpn
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Nakamura Chizuko
Department Of Pharmacy Kumamoto University Hospital
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Arimori K
Department Of Pharmacy Miyazaki Medical College Hospital
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Arimori Kazuhiko
Department Of Pharmacy Kumamoto University Hospital
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Nakano Masahiro
Deparment Of Physics Kyushu University
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Arimori Kazuhiko
Department Of Pharmacy Faculty Of Medicine University Of Miyazaki
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