Inhibitory Effects of Amino-Acid Fluids on Drug Binding to Site II of Human Serum Albumin in Vitro(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
The effects of amino-acid fluids on ligand binding to human serum albumin (HSA) were investigated by fluorescence and ultrafiltration techniques. Warfarin and dansylsarcosine were used as the site marker fluorescence probes for site I and site II of HSA, respectively. Amino-acid fluids specifically decreased the fluorescence intensity induced by dansylsarcosine-HSA binding without any effects on that induced by warfarin-HSA binding. The ultrafiltration technique clarified that the free fraction of the site II drug, diazepam, in human serum was increased in the presence of amino-acid fluids, while no effect was observed in the free fraction of the site I drug, warfarin. The potencies of the effect on binding to site II, observed by fluorescence and ultrafiltration techniques, correlated well with the L-tryptophan contents in amino-acid fluids or with those in L-tryptophan solutions. Based on the comparison between the effects of amino-acid fluids and L-tryptophan solutions, we confirmed that L-tryptophan in amino-acid fluids specifically inhibits drug binding to site II of HSA.
- 公益社団法人日本薬学会の論文
- 2005-03-01
著者
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Nishi R
Department Of Radiology Miyazaki Medical College
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Nishii Ryuichi
Department Of Experimental Diagnostic Imaging University Of Texas Md Anderson Cancer Center
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KAWAI Keiichi
School of Health Sciences, Faculty of Medicine, Kanazawa University
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Nishii R
Department Of Radiology Miyazaki Medical College
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Kai Hirofumi
Dep. Of Molecular Medicine Fac. Of Medical And Pharmaceutical Sciences Kumamoto Univ.
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Okumura Manabu
Department Of Pharmacy Miyazaki Medical College Hospital
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Okumura Manabu
Tokyo Institute Of Technology Precision And Intelligence Laboratory
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Okumura Manabu
Department Of Computer Science Japan Advanced Institute Of Science And Technology
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ARIMORI Kazuhiko
Department of Pharmacy, Miyazaki Medical College Hospital
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HIDAKA Muneaki
Department of Pharmacy, Miyazaki Medical College Hospital
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KODAMA HIROFUMI
Department of Pharmacy, Miyazaki Medical College Hospital
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KUGA Noriyuki
Department of Radiology, Technology Miyazaki Medical College Hospital
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Okumura M
Dep. Of Pharmacy Univ. Of Miyazaki Hospital
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Kuga Noriyuki
Department Of Radiology Miyazaki Medical College
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Kawai Keiichi
School Of Health Sciences Faculty Of Medicine Kanazawa University
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Hidaka Muneaki
Department Of Pharmacy Miyazaki Medical College Hospital
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YAMASAKI Keishi
Department of Pharmacy, Miyazaki Medical College Hospital
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TAKAMURA Norito
School of Pharmaceutical Sciences, Kyusyu University of Health and Welfare
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FURUYA Yumiko
Department of Pharmacy, Miyazaki Medical College Hospital
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IWAKIRI Tomomi
Department of Pharmacy, Miyazaki Medical College Hospital
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NISHII Ryuuichi
Department of Radiology, Miyazaki Medical College
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Furuya Yumiko
Department Of Pharmacy Miyazaki Medical College Hospital
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Iwakiri Tomomi
Department Of Pharmacy Miyazaki Medical College Hospital
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Yamasaki Keishi
Dep. Of Pharmacy Univ. Of Miyazaki Hospital
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Nishii Ryuuichi
Department Of Radiology Miyazaki Medical College
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Kodama Hirofumi
Department Of Molecular Medicine Faculty Of Medical And Pharmaceutical Sciences Kumamoto University
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Yamasaki Keishi
Department Of Pharmacy University Of Miyazaki Hospital
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Takamura Norito
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Arimori Kazuhiko
Department Of Pharmacy Miyazaki Medical College Hospital
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Arimori Kazuhiko
Department Of Pharmacy Kumamoto University Hospital
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Arimori Kazuhiko
Department Of Pharmacy Faculty Of Medicine University Of Miyazaki
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Hidaka Muneaki
Department Of Pharmacy Faculty Of Medicine University Of Miyazaki
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HIDAKA Muneaki
Department of Biochemistry, Microbiology, and Clinical Pharmacy, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare
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