Effect of Clarithromycin and Other Macrolides on the Sulfoxidation and 5-Hydroxylation of Lansoprazole in Dogs
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this study was to evaluate a possible interaction between lansoprazole and clarithromycin as well as other macrolides in dogs. Lansoprazole (30 mg) was orally administered to male beagle dogs, with or without oral pretreatment with 200-mg clarithromycin twice a day for 5 d. The experiments had a randomized cross-over design with a two-week washout period between dosing regimens. Clarithromycin pretreatment for 5 d resulted in a significant increase in the area under the serum lansoprazole concentration-time curve (AUC), whereas the area for a lansoprazole metabolite, lansoprazole sulfone, was significantly reduced, as was the maximum serum concentration (C_<max>) of lansoprazole sulfone. When the effects of clarithromycin on the metabolism of lansoprazole were studied using dog liver microsomes, it was found that clarithromycin significantly inhibited the formation of lansoprazole sulfone but not another metabolite, 5-hydroxylansoprazole. These results suggest that co-medication of lansoprazole with clarithromycin may produce a synergistic effect caused by the increased serum levels of lansoprazole of benefit in Helicobacter pylori eradication.
- 公益社団法人日本薬学会の論文
- 1999-05-15
著者
-
MIYAMOTO Shinji
Department of Laboratory Medicine, National Defense Medical College
-
Miyamoto Shinji
Department Of Cardiovascular Surgery Oita University Faculty Of Medicine
-
NAKANO Masahiro
Department of Physics, Kyoto University
-
FUJII Junko
Department of Pharmaceutical Services, Kumamoto University Hospital
-
FUJII Junko
熊本大学医学部附属病院薬剤部
-
Nakano M
Department Of Information Science University Of Occupational And Environmental Health
-
Fujii J
熊本大学医学部附属病院薬剤部
-
Fujii Junko
Department Of Pharmacy Kumamoto University Hospital
-
Fujii Junko
Department Of Pharmaceutical Services Kumamoto University Hospital
-
ARIMORI Kazuhiko
Department of Pharmacy, Miyazaki Medical College Hospital
-
MASA Kengo
Department of Pharmacy, Kumamoto University Hospital
-
NAKAYAMA Takao
Department of Pharmacy, Kumamoto University Hospital
-
Nakano M
University Of Occupational And Environmental Health
-
Nakano M
Department Of Biologicalsciences Teikyo University Of Science And Technology
-
Miyamoto Shinji
Department Of Pharmacy Kumamoto University Hospital
-
Nakano Masahiro
Department Of Biologicalsciences Teikyo University Of Science And Technology
-
Masa Kengo
Department Of Pharmacy Kumamoto University Hospital
-
Nakayama Takao
Department Of Pharmacy Kumamoto University Hospital
-
Nakano M
Univ. Occupational And Environmental Health Jpn
-
Arimori K
Department Of Pharmacy Miyazaki Medical College Hospital
-
Arimori Kazuhiko
Department Of Pharmacy Kumamoto University Hospital
-
Nakano Masahiro
Deparment Of Physics Kyushu University
-
Miyamoto Shinji
Department Of Cardiovascular Surgery Faculty Of Medicine Oita University
-
Arimori Kazuhiko
Department Of Pharmacy Faculty Of Medicine University Of Miyazaki
-
NAKANO Masahiro
Department of Physics, Kyushu University:Department of Physics, Saga University
-
FUJII Junko
Department of Nutrition, Saiseikai Noe Hospital
関連論文
- T-Square Term of Electrical Resistivity : Condensed Matter and Statistical Physics
- A case of rheumatoid arthritis that developed autoimmune hepatitis associated with anti-Golgi complex antibody
- Intraoperative bronchoscopic resection of a papillary fibroelastoma in the left ventricular outflow tract after aortic mechanical valve replacement
- Simplified Elephant Trunk Technique Promotes Thrombo-Occlusion of the False Lumen in Acute Type A Aortic Dissection
- Effect of Prostaglandin E_1 on Ischemia-Reperfusion Injury During Abdominal Aortic Aneurysm Surgery
- Reversal of Delayed-onset Paraplegia with Thrombectomy of an Interposed Graft for the Intercostal Artery after Thoracic Descending Aortic Aneurysm Repair
- Aortic Valve Lipomatous Hamartoma in a Young Woman
- Successful Surgical Treatment of Heart Failure and Ventricular Tachycardia in a Patient With Arrhythmogenic Right Ventricular Dysplasia With Cardiomyopathy
- Limb Ischemia and Reperfusion During Abdominal Aortic Aneurysm Surgery
- MRSA Aortic Valve Endocarditis Treated by Pericardium-lined Dacron Patch and Vancomycin-Containing Fibrin Glue
- Denervation and Reinnervation of the Heart After Aortic Surgery, Estimated by ^I-Metaiodobenzylguanidine Scintigraphy
- Patency of Saphenous Vein Coronary Artery Bypass Grafts from the Vascular Prosthesis of the Ascending Aorta
- Successful Treatment of a Salmonella Aortic Arch Aneurysm
- An Easy, Safe, and Sure Way of Open Stent Grafting : Chain-Stitch Bonding with a Balloon Catheter
- Acute Myocardial Infarction due to Left Main Coronary Artery Occlusion : Therapeutic Strategy
- Successful Open Stent Grafting of a Right Aortic Arch and a Descending Aortic Aneurysm Originating from a Kommerell's Diverticulum : Report of a Case
- Left Ventricular Free Wall Rupture possibly induced by Coronary Spasm Surgical Repair in the Emergency Room
- Surgical Treatment of Abdominal Aortic Aneurysms Located Close to the Visceral Arteries : Report of Three Cases
- Improved Hypertrophic Obstructive Cardiomyopathy by Left Ventricular Apex Epicardial Pacing
- PE-443 Protective Effect of Prostaglandin E1 for Ischemia and Reperfusion during Abdominal Aortic Aneurysm Operation(Peripheral Circulation/Vascular Disease 4(H) : PE75)(Poster Session (English))
- Rupture into the Esophagus of Multiple Thoracic Aortic Aneurysms Arising from an Anomalous Aortic Arch
- Repair of a Ruptured Aortic Arch Aneurysm Complicated by Postoperative Paraplegia : Report of a Case
- -0549- CLINICAL AND PATHOLOGICAL FEATURES OF THE IDIOPATHIC AORTIC REGURGITATION(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Logistic Regression Analysis of Inherited Polymorphism as Modulators of Stomach Cancer
- RELATIVE BIOAVAILABILITY OF MIDAZOLAM FOLLOWING SUBLINGUAL VERSUS ORAL ADMINISTRATION IN HEALTHY VOLUNTEERS
- Studies on Pharmacokinetics of Ethotoin in Epileptic Children and Adolescents Using a Stable Isotope
- Effect of Food on the Bioavailability of Bromazepam Following Oral Administration in Healthy Volunteers
- CLINICAL PHARMACOLOGICAL STUDIES OF ETHOTOIN IN PEDIATRIC EPILEPTIC PATIENTS
- New developments in INC model for medical application(Contribution to 21 Century Intelligent Technologies and Bioinformatics)
- STUDY ON NASAL ABSORPTION OF POLYPEPTIDES. EXAMINATION OF ABSORPTION PROMOTERS
- Development of a rapid assay for screening point mutations associated with quinolone resistance in the Pseudomonas aeruginosa parC gene
- Antimicrobial Activity of a New Fluoroquinolone, DU-6859a, against Quinolone-Resistant Clinical Isolates of Pseudomonas aeruginosa with Genetic Alterations in the GyrA Subunit of DNA Gyrase and the ParC Subunit of Topoisomerase IV
- Significance of Stenotrophomonas maltophilia in Urinary Tract Infections
- Comparison of urethral diameters for calculating the urethral dose after permanent prostate brachytherapy
- CT-based postimplant dosimetry of prostate brachytherapy : comparison of 1-mm and 5-mm section CT
- The potential role of prebiopsy magnetic resonance imaging combined with prostate-specific antigen density in the detection of prostate cancer
- Measurement of Concentrations of Nicotine and Cotinine in Maternal and Neonatal Hair
- Examination of Stability of Anticonvulsants in a Protease Solution and Assay of Anticonvulsants in Hairs
- Acyclothymidine Alleviates Intestinal Toxicity of 5'-Deoxy-5-fluorouridine without Loss of Antitumor Activity in Mice
- Modulation of the Pharmacokinetics of 5'-Deoxy-5-fluorouridine and 5-Fluorouracil in Rats by Oral Co-administration of Acyclothymidine
- Anticancer Activity of Free γ-Linolenic Acid on AH-109A Rat Hepatoma Cells and the Effect of Serum Albumin on Anticancer Activity of γ-Linolenic Acid in Vitro
- Hydrolysis of 3', 5'-Dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8) in Rabbit and Human Plasma and Its Release from Oily Solution
- Bromocriptine Reverses P-Glycoprotein-mediated Multidrug Resistance in Tumor Cells
- Bromocriptine Reverses P-Glycoprotein-mediated Multidrug Resistance in Tumor Cells
- High-performance liquid chromatographic assay for the simultaneous determination of lansoprazole enantiomers and metabolites in human liver microsomes
- Increase in Doxorubicin Cytotoxicity by Inhibition of P-glycoprotein Activity with Lomerizine
- Pharmacokinetic Differences between Lansoprazole Enantiomers and Contribution of Cytochrome P450 Isoforms to Enantioselective Metabolism of Lansoprazole in Dogs
- Inhibitory Effect of Human Immunodeficiency Virus Protease Inhibtors on Multidrug Resistance Transporter P-Glycoproteins
- Effect of Clarithromycin and Other Macrolides on the Sulfoxidation and 5-Hydroxylation of Lansoprazole in Dogs
- Inhibition of 5'-Deoxy-5-fluorouridine Phosphorolysis by Acyclothymidine in Tumor Cell Homogenates
- Effects of Betamipron on Cisplatin Nephrotoxicity and Its Pharmacokinetics in Rats
- Protective Effects of N-Benzoyl Amino Acids on Cisplatin Nephrotoxicity in Rats
- Urothelial Cancer Risk in Relation to Genotypes of Glutathione S-Transferase (GST) M1, T1, P1 and N-Acetyltransferase 2 (NAT2), and Tobacco Smoking
- Roles of Hydrophobicity, Protein Binding and the Probenecid-Sensitive Transport System in the Cerebrospinal Fluid Delivery of Nucleoside Analogues with Anti-viral Activity
- Theoretical and experimental studies to remove a stench around a bedside
- Paleoenvironments in the Last Glacial Maximum around the Naka-Ikemi Moor, Fukui Prefecture,central Japan
- Roles of Hydrophobicity, Protein Binding and the Probenecid-Sensitive Transport System in the Cerebrospinal Fluid Deliveryof Nucleoside Analogues with Anti-Viral Activity
- Enhanced Fecal Excretion of Bile Acids by a New Anion-Exchange Resin Possessing a Spacer Arm in Rats
- Fluctuation and Complex Stochastic Dynamics : From Micro-system to Macro-system
- Hemodynamic Profiles During Concurrent Intraaortic Balloon Pumping and Venoarterial Bypass : A Canine Study Comparing Subclavian and Femoral Artery Perfusion Sites
- Estrogen receptor α gene ESR1 amplification may predict endocrine therapy responsiveness in breast cancer patients
- Comparative Study of Two Preparation Methods of w/o/w Emulsions : Stirring and Membrane Emulsification
- Promotion of Nasal Absorption of Insulin by Glycyrrhetinic Acid Derivatives. I
- STUDIES ON THE PROMOTING EFFECTS OF MEDIUM CHAIN FATTY ACID SALTS ON THE NASAL ABSORPTION OF INSULIN IN RATS
- Power Durability of Al-W Alloy Electrodes Used in RF-Band Surface Acoustic Wave Filters
- The Power Durability of 900 MHz Band Double-Mode-Type Surface Acoustic Wave Filters and Improvement in Power Durability of Al-Cu Thin Film Electrodes by Cu Atom Segregation
- PREPARATION AND EVALUATION OF W/O TYPE AND W/O/W TYPE EMULSIONS CONTAINING AN ANTICANCER DRUG
- Failure to detect Mycoplasma genitalium in the pharynges of female sex workers in Japan
- Angle-Dependent Quantum-Oscillations due to Chemical Potential Oscillation in Quasi-Two-Dimensional Multiband Fermi Liquids
- dHvA Effect with Quantum Interference Oscillation due to Magnetic Breakdown
- Theory of Field-Induced Spin Density Wave States in Anisotropic Two-Dimensional Electron Systems
- Measurements of Optical Trapping Efficiency for Micron-Sized Dielectric Particles in Various Surrounding Media
- Deforestation in eastern and central nepal
- Effect of HIV on Japanese Population in 2050
- Bifurcations, Problems on Quantum Computation, And Our New Theory of Calculations
- Clathrate hydrates as a phase of H_2O molecules
- Actin Myosin Systems Based on the Stochastic Resonance
- EVALUATION OF ORALLY ADMINISTERED ACTIVATED CHARCOAL ON INTESTINAL DIALYSIS OF INTRAVENOUSLY ADMINISTERED M79175,AN ALDOSE REDUCTASE INHIBITOR, IN RATS
- EFFECT OF ACTIVATED CARBON BEADS ON SERUM LIPID LEVELS AND FECAL BILE ACID EXCRETION IN RATS
- Evaluation of Percutaneous Absorption of Midazolam by Terpenes
- Non-Perturbative Renormalization Group Equations in Quantum Hadrodynamics
- Antiproton Production in p + d Reaction at Subthreshold Energies
- Meson-Nucleon Vertex Corrections in the Cutoff Field Theory and Tensor Coupling
- Vacuum Effects and Compressional Properties of Nuclear Matter in Cutoff Field Theory : Nuclear Physics
- Effects of Ring Diagrams in the Asymmetric Nuclear Matter : Nuclear Physics
- Properties of Nuclear Matter in Cutoff Field Theory and the Low-Energy Effective Lagrangian in the Hartree Approximation : Nuclear Physics
- Clinical significance of basal-like subtype in triple-negative breast cancer
- PREPARATION AND EVALUATION OF POLYLACTIC ACID MICROSPHERES CONTAINING AN ANTICANCER DRUG
- Atherosclerotic Aneurysm of the Intrathoracic Segment of the Subclavian Artery : A Case Report
- Compressional Properties of Nuclear Matter in the Relativistic Mean Field Theory with the Excluded Volume Effects
- Nucleon Mean Free Path in Nuclear Matter Based on Nuclear Schwinger Dyson Formalism
- Early and Long-term Results of Cardiovascular Surgery in Octogenarians
- Ascending Aortic Infected Pseudoaneurysm with Aortic Insufficiency Following Cardiac Operation for Infective Endocarditis
- Optical Potentials near Fermi Surface by Nuclear Schwinger-Dyson Equations with Bare Vertex Approximation
- Evaluation of One Meson Loop Corrections for Nuclear Matter by Nuclear Schwinger-Dyson Equations with Bare Vertex Approximation : Nuclear Physics
- Preparation of and Drug Release from W/O/W Type Double Emulsions Containing Anticancer Agents Using an Oily Lymphographic Agent as an Oil Phase(Pharmaceutical)
- A13-106 DOUBLE SPRING NANO-MOLECULAR MACHINE MODEL (DS-NMM) USING THERMAL FLUCTUATION AND CHEMICAL ENERGY
- PREPARATION AND EVALUATION OF PHENOBARBITAL SUPPOSITORIES FOR FAST ABSORPTION
- TRANSPORT OF DRUGS INTO THE INTESTINAL LUMEN AND THE EFFECT OF ORAL ADMINISTRATION OF ACTIVATED CHARCOAL ON SERUM CLEARANCE OF DRUGS FOLLOWING. i.v. ADMINISTRATION TO RATS
- Initial in vivo evaluation of the newly developed axial flow turbo pump with hydrodynamic bearings