Effect of Food on the Bioavailability of Bromazepam Following Oral Administration in Healthy Volunteers

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The effect of food on the rate and extent of bioavailability of bromazepam was examined in seven normal volunteers following a single oral dose of 10 mg bromazepam with 200 ml of water in the fasting and non-fasting states. Plasma concentrations of bromazepam were measured by high pressure liquid chromatography. A t_<max> value in a non-fasting state was prolonged from 2.3±0.3 (mean ±S.E.M) to 2.8±0.6 h but not significantly different (p > 0.05) whereas a C_<max> value was significantly (p < 0.05) decreased from 259±12.7 (mean ±S.E.M.) to 169±13.9 ng/ml. The area under the plasma concentration-time curve in the non-fasting state was also significantly (p < 0.05) decreased from 1844±145 (mean ±S.E.M.) to 1233±98.1 ng・h/ml after oral administration of bromazepam.
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