DURATION OF THE LOCAL ANESTHETIC EFFECT OF TETRACAINE HYDROCHLORIDE SOLUTIONS AND TETRACAINE IN MICROSPHERES
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概要
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The local anesthetic effect of tetracaine in polylactic acid microspheres was compared with that of tetracaine hydrochloride solutions. As a first step, the local anesthetic effect of 0.1 ml tetracaine hydrochloride solutions was examined at four concentrations in vivo. Then, the local anesthetic effect of 0.2 ml tetracaine hydrochloride solutions was compared with that of 0.1 ml tetracaine hydrochloride solutions. The more the amount of tetracaine, the stronger and longer was the local anesthetic effect. The local anesthetic effect of tetracaine in microspheres was much longer and lasted over 100 h.
- 公益社団法人日本薬学会の論文
著者
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Juni Kazuhiko
Department Of Pharmacy Kumamoto University Hospital
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Nakano Masahiro
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Wakiyama Naoki
Faculty Of Pharmaceutical Sciences Hokkaido University
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Nakano Masahiro
Deparment Of Physics Kyushu University
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