Correlation between salivary and plasma levels of acetaminophen.
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概要
- 論文の詳細を見る
A single oral dose of 500 mg of acetaminophen was administered to each of six female volunteers. Twenty-four paired plasma and saliva samples were obtained and the saliva to-plasma concentration ratio (S/P) was determined to be 0. 95 with a correlation coefficient of 0. 966. No significant difference was observed between the ratios for the absorption phase and for the elimination phase, although during the absorption phase salivary levels showed a slightly higher tendency than the corresponding plasma levels, and during elim ination, vice versa. Thus, pharmacokinetic parameters were calculated from the salivary levels alone on the basis of a one-compartment open model as well as moment analysis.
- 一般社団法人 日本臨床薬理学会の論文
著者
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Nakano Masahiro
Deparment Of Physics Kyushu University
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IWASAKA Kaoru
Ginkyo College of Medical Science
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FUNADA Shoko
Ginkyo College of Medical Science
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NAKANO Naomi
Ginkyo College of Medical Science
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