ACCELERATED CLEARANCE OF INTRAVENOUSLY ADMINISTERED THEOPHYLLINE AND PHENOBARBITAL BY ORAL DOSES OF ACTIVATED CHARCOAL IN RATS. A POSSIBILITY OF THE INTESTINAL DIALYSIS
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概要
- 論文の詳細を見る
The effect of oral administration of activated charcoal on the clearance of theophylline and phenobarbital following their intravenous administration was studied in rats. Oral administration of multiple doses of activated charcoal significantly decreased the serum half-life and AUC (area under the curve) and increased the total body clearance of both theophylline and phenobarbital as compared with their respective controls. The volume of distribution was not significantly different between treatments. A single dose of activated charcoal showed only a slight enhancement of clearance of theophylline. Accelerated clearance of both drugs by oral activated charcoal was rationalized in terms of adsorption of exsorbed drugs and inhibition of their reabsorption by activated charcoal in the gastrointestinal tract.
- 公益社団法人日本薬学会の論文
著者
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Nakano Masahiro
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Nakano Masahiro
Department Of Pharmacy Kumamoto University Hospital
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Arimori Kazuhiko
Department Of Pharmacy Kumamoto University Hospital
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Nakano Masahiro
Deparment Of Physics Kyushu University
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Arimori Kazuhiko
Department Of Pharmacy Faculty Of Medicine University Of Miyazaki
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