Pharmacokinetics of Intravenous Famotidine in Elderly Patients with and without Renal Insufficiency and in Healthy Young Volunteers.
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概要
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The pharmacokinetics of famotidine were studied in 7 elderly patients with normal renalfunction, 5 elderly patients with moderate renal insufficiency, 8 anuric elderly patients, and6 healthy young volunteers after intravenous administration of a 10 mg dose .<BR>Although the elimination half-life was not significantly different among the elderly patients with moderate renal insufficiency, the elderly patients with normal renal function, andthe young healthy volunteers, it was considerably prolonged in the anuric elderly patients .There was a good correlation between creatinine clearance estimated by their serum creatinine concentration and the elimination rate constant of famotidine (r=0.754).
- 一般社団法人 日本臨床薬理学会の論文
著者
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Inotsume Nobuo
Department Of Hospital Pharmacy School Of Medicine Tokyo Medical And Dental University
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Nakano Masahiro
Deparment Of Physics Kyushu University
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SATO Tatsuo
Third Department of Internal Medicine Medical School, Kumamoto University.
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ONIKI Mayumi
Department of Pharmacy, Kumamoto University Hospital
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INOTSUME Nobuo
Department of Pharmacy, Kumamoto University Hospital
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TAKESHITA Seiichi
Third Department of Internal Medicine, Kumamoto University School of Medicine
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FUJIYAMA Shigefumi
Third Department of Internal Medicine, Kumamoto University School of Medicine
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MATSUSHITA Kazutaka
Akebono Clinic
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