(Na++K+) ATPase inhibitors and intracellular electrolytes in essential hypertension.

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概要

• 論文の詳細を見る

• White blood cell (WBC) Na+ and K+ concentrations, plasma (Na++K+)ATPase inhibition and blood pressure were determined in normotensive control subjects and patients with essential hypertension. While the untreated hypertensive group had significantly lower WBC K+ concentrations than the normotensive group (mean±SEM, 121.6±4.4vs. 134.7±2.8mEq/kg, p<0.05), no significant difference was observed in WBC Na+ concentrations between the 2 groups. The mean of plasma (Na++K+)ATPase inhibition in untreated hypertensive patients was higher than that in normotensive controls (14.8±1.7vs. 7.2±1.8%, p<0.05). The correlations between (Na++K+) ATPase inhibition and mean blood pressure and between WBC Na+/K+ ratio and mean blood pressure were significant (r=0.278, p<0.05 and 0.270, p<0.05, respectively), but both were weak. However, untreated hypertensive patients with higher (Na++K+)ATPase inhibition had significantly higher WBC Na+/K+ ratios than untreated patients with less (Na++K+) ATPase inhibition. These results suggest a contribution of plasma (Na++K+) ATPase inhibition in the production of high blood pressure in a subset of patients with essential hypertension, which results in altered intracellular K+ concentrations.

• International Heart Journal刊行会の論文

著者

• SATO Tatsuo

  Third Department of Internal Medicine Medical School, Kumamoto University.

• IWAOKA Taisuke

  Third Department of Internal Medicine Kumamoto University Medical School

• UMEDA Teruhisa

  Third Department of Internal Medicine Kumamoto University Medical School

• NUGENT Charles

  Endocrine Section, Department of Internal Medicine, VA Medical Center and the University of Arizona College of Medicine

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