Accelerated elimination of phenobarbital by oral activated charcoal suspensions with alkaline diuresis in an overdose patient.
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概要
- 論文の詳細を見る
A patient with phenobarbital overdose was treated with gastric administration of multiple doses of activated charcoal suspensions with alkaline diuresis. The decline of serum phenobarbital concentrations was sharper during the therapy than a control period. Elimination half-lives of phenobarbital of 15. 5 and 39. 1 h were obtained for the period of charcoal treatment with and without alkaline diuresis, respectively. As a normal elimination half-life of the patient was 82. 2 h, combined use of oral activated charcoal with alkaline diuresis proved to be an effective, safe, and inexpensive therapeutic measure in a case of phenobarbital overdose.
- 一般社団法人 日本臨床薬理学会の論文
著者
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HIGASHI Akimasa
Department of Pediatrics, Kumamoto University Medical School
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Inotsume Nobuo
Department Of Hospital Pharmacy School Of Medicine Tokyo Medical And Dental University
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Katsuya Hirotada
Intensive Care Unit Of Kumamoto University Hospital
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Nakano Masahiro
Deparment Of Physics Kyushu University
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KATSUYA Hirotada
Intensive Care Unit, Kumamoto University Hospital
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KIMOTO Akihiko
Intensive Care Unit, Kumamoto University Hospital
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