EFFECT OF ACTIVATED CARBON BEADS ON SERUM LIPID LEVELS AND FECAL BILE ACID EXCRETION IN RATS
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概要
- 論文の詳細を見る
The effects of oral activated carbon beads on the total serum cholesterol and triglyceride levels and on the fecal bile acid excretion in rats fed a basal or high cholesterol diet containing 5% activated carbon beads for 6 weeks were investigated. The beads appeared to exert little effect on the growth rate of rats and no tendency towards constipation was also observed. Although treatment with activated carbon beads gave little influence on the total serum cholesterol and serum triglyceride levels in rats fed either a basal or high cholesterol diet, the beads did produce a significant rise in the total fecal bile acid excretion. The extra fecal bile acids resulted chiefly from an increase in lithocholic acid. Furthermore, the beads showed a tendency to inhibit absorption of dietary cholesterol from the gastrointestinal tract in rats fed a high cholesterol diet. These results suggested the possibility of activated carbon beads as a hypocholesterolemic agent through binding with bile acids in the intestine.
- 公益社団法人日本薬学会の論文
著者
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NAKANO Masahiro
Department of Physics, Kyoto University
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HONDA Yoshiteru
Department of Pharmacy, Kumamoto University Hospital
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Nakano Masahiro
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Nakano N
Ginkyo Coll. Medical Science Kumamoto Jpn
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I.NAKANO NAOMI
Department of Pharmacy, Kumamoto University Hospital
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Honda Yoshiteru
熊本大学医学部附属病院 薬剤
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Honda Yoshiteru
Department Of Pharmacy Kumamoto University Hospital
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Nakano Masahiro
Deparment Of Physics Kyushu University
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NAKANO MASAHIRO
Department of Pharmacy, Kumamoto University Hospital:Ginkyo College of Medical Science
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