RELATIVE BIOAVAILABILITY OF MIDAZOLAM FOLLOWING SUBLINGUAL VERSUS ORAL ADMINISTRATION IN HEALTHY VOLUNTEERS
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概要
- 論文の詳細を見る
The extent of bioavailability of midazolam following sublingual and oral administration were evaluated. Three healthy volunteers received a single 15-mg dose of midazolam maleate by sublingual and oral routes on two occasions in a ossover design. Concentrations of midazolam in plasma during 4 h after each dose were measured by gasliquid chromatography with an electron-capture detector. The mean AUC_<0-4> value following sublingual administration was significantly greater than that following oral administration (14889 vs 3594 ng・min/ml, p<0.05). The peak plasma concentration after sublingual dose was also singificantly higher than that after oral administration (p<0.05). The mean AUC_<0-4> value of midazolam after sublingual administration was increased four times compared with that after oral administration, possibly due to avoidance of first-pass effect. Thus, the clinical effects of midazolam may likewise be enhanced by sublingual administration of midazolam.
- 社団法人日本薬学会の論文
著者
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Nakanuma Yasuni
金沢大学がん研究所 腫瘍内科
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NAKANO Masahiro
Department of Physics, Kyoto University
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Kurumaya Hiroshi
Department Of Pathology Ishikawa Prefectural Central Hospital
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Inotsume Nobuo
Department Of Pharmaceutical Services Kumamoto University Hospital
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FUJII Junko
Department of Pharmaceutical Services, Kumamoto University Hospital
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Fujii Junko
Department Of Pharmaceutical Services Kumamoto University Hospital
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Nakano Masahiro
Department Of Pathology School Of Medicine Ehime University
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Inotsume Nobuo
Department Of Hospital Pharmacy School Of Medicine Tokyo Medical And Dental University
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Nakano Masahiro
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Nagao Yasuyuki
Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakanuma Yasuni
Department Of Human Pathology Graduate School Of Medical Science Kanazawa University
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Nakano Masahiro
Deparment Of Physics Kyushu University
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FUJII Junko
Department of Nutrition, Saiseikai Noe Hospital
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