Examination of Stability of Anticonvulsants in a Protease Solution and Assay of Anticonvulsants in Hairs
スポンサーリンク
概要
- 論文の詳細を見る
For analyzing the concentrations of drugs in hairs, a new method of digestion of hairs with Biopurase^<[○!R]>, a protease obtained from Bacillus subtilis, was examined. The concentrations of drugs in hairs were then determined in order to examine the usefulness of the protease for the digestion of hairs.The stability of five anticonvulsants in the protease solution was maintained over a 12-h period. In the clinical tests, the concentrations of the drugs in hairs obtained from patients who were taking anticonvulsants for a long time were determined. The concentration of phenobarbital in hairs in 10 patients taking phenobarbital ranged from 194 to 5020 ng/10 mg with a mean of 578 ng/10 mg, and the concentration of phenytoin in hairs in 6 patients taking phenytoin ranged from 44 to 299 ng/10 mg with a mean of 115 ng/10 mg. From these results, the transfer of phenobarbital and phenytoin from circulating blood into hairs was confirmed, and the usefulness of Biopurase^<[○!R]> for the digestion of hairs was proved.
- 公益社団法人日本薬学会の論文
- 1996-12-15
著者
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NAKANO Masahiro
Department of Physics, Kyoto University
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Nakano Masahiro
熊本大学医学部附属病院 薬剤
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FUJII Junko
Department of Pharmaceutical Services, Kumamoto University Hospital
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FUJII Junko
熊本大学医学部附属病院薬剤部
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HIGASHI Akimasa
熊本大学医学部小児科
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HIGASHI Akimasa
Department of Pediatrics, Kumamoto University Medical School
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Nakano M
Department Of Information Science University Of Occupational And Environmental Health
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Fujii J
熊本大学医学部附属病院薬剤部
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Fujii Junko
Department Of Pharmacy Kumamoto University Hospital
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Fujii Junko
Department Of Pharmaceutical Services Kumamoto University Hospital
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Nakano M
University Of Occupational And Environmental Health
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Nakano M
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Nakano Masahiro
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Higashi Atsuya
Analysis & Quality Control Department Takeda Chemical Industries Ltd.
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Nakano M
Univ. Occupational And Environmental Health Jpn
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Nakano Masahiro
Deparment Of Physics Kyushu University
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FUJII Junko
Department of Nutrition, Saiseikai Noe Hospital
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