Compositional Analysis of Copoly(DL-Lactic/Glycolic Acid)(PLGA)by Pyrolysis-Gas Chromatography/Mass Spectrometry Combined with One-step Thermally Assisted Hydrolysis and Methylation in the Presence of Tetramethylammonium Hydroxide
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概要
- 論文の詳細を見る
Rapid and precise compositional analysis of copoly(DL-lactic/glycolic acid)(PLGA)was performed by pyrolysis-gas chromatography/mass spectrometry(Py-GC/MS)combined with one-step hydrolysis and methylation in the presence of tetramethylammonium hydroxide(TMAH). Pyrolysis of PLGA with TMAH gave two characteristic products, derivatives of DL-lactic acid and glycolic acid, which directly reflect the average molar composition of PLGA. The analytical results for PLGA samples with various compositional ratios were in good agreement with those obtained by ^1H-NMR spectrometry, and the precision was satisfactory.
- 公益社団法人日本薬学会の論文
- 2001-02-01
著者
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HIGASHI Akimasa
熊本大学医学部小児科
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Hashimoto K
Kyoto Pharmaceutical University
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Hashimoto Keiji
Nagahama Institute Of Bio-sciences And Technology
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HASHIMOTO Keiji
Kyoto Pharmaceutical University
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Hashimoto K
Nagahama Institute Of Bio-sciences And Technology
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Urakami Koji
Analysis & Quality Control Department Takeda Chemical Industries Ltd.
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HIGASHI Atsuya
Analysis & Quality Control Department, Takeda Chemical Industries, Ltd.
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UMEMOTO Kazuichi
Analysis & Quality Control Department, Takeda Chemical Industries, Ltd.
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GODO Masayuki
Analysis & Quality Control Department, Takeda Chemical Industries, Ltd.
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WATANABE Chuichi
Frontier LAB, Co., Ltd.
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Godo Masayuki
Analytical Development Laboratories Takeda Chemical Industries Ltd.
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Higashi Atsuya
Analysis & Quality Control Department Takeda Chemical Industries Ltd.
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Umemoto K
Analytical Development Laboratories Takeda Chemical Industries Ltd.
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Watanabe C
Frontier Laboratories Ltd.
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HASHIMOTO Keiji
Kyoto College of Pharmacy
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