Structural Study of PLGA [Copoly (DL-Lactic/Glycolic Acid)], a Biodegradable Polymer for Parenteral Sustained Release Preparations, by Tandem Mass Spectrometry
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概要
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A copoly (DL-lactic/glycolic acid) (PLGA), with a weight-average molecular weight of about 8400,has been characterized using fast atom bombardment (FAB)-tandem mass spectrometry in order to determine the sequence. Because of the large molecular size, PLGA was partially hydrolyzed and the terminal hydroxyl groups in the resulting oligomer mixture acetylated as the indicator. The FAB spectrum of this sample showed a complex ion signal pattern containing monomer to octamer. Diagnostic product ions containing useful information for sequence determination were observed in collision-induced dissociation-MS/MS and MS/MS/MS of these oligomer ions. The results of analysis for dimers through pentamers showed that they have random sequences of lactic and glycolic acid, suggesting that the whole structure of PLGA also has a random sequence.
- 公益社団法人日本薬学会の論文
- 1999-08-15
著者
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Hashimoto K
Kyoto Pharmaceutical University
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Hashimoto Keiji
Nagahama Institute Of Bio-sciences And Technology
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HASHIMOTO Keiji
Kyoto Pharmaceutical University
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Akimoto Naoshige
Graduate School Of Pharmaceutical Sciences; Kyoto University
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Akimoto Naoshige
Faculty Of Pharmaceutical Sciences Kyoto University
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NISHIJIMA Koji
Drug Analysis & Pharmacokinetics Research Laboratories, Pharmaceutical Development Division, Takeda
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Hashimoto K
Nagahama Institute Of Bio-sciences And Technology
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URAKAMI Koji
Drug Analysis & Pharmacokinetics Research Laboratories, Takeda Chemical Industries, Ltd.,
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KITANAKA Yutaka
Drug Analysis & Pharmacokinetics Research Laboratories, Takeda Chemical Industries, Ltd.,
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ECHIGOYA Midori
Drug Analysis & Pharmacokinetics Research Laboratories, Takeda Chemical Industries, Ltd.,
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Urakami Koji
Analysis & Quality Control Department Takeda Chemical Industries Ltd.
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Kitanaka Yutaka
Drug Analysis & Pharmacokinetics Research Laboratories Takeda Chemical Industries Ltd.
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Echigoya Midori
Drug Analysis & Pharmacokinetics Research Laboratories Takeda Chemical Industries Ltd.
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HASHIMOTO Keiji
Kyoto College of Pharmacy
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