Effects of Erythromycin, Clarithromycin and Rokitamycin on Nifedipine Metabolism in Rats
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概要
- 論文の詳細を見る
The effects of erythromycin, clarithromycin and rokitamycin on the metabolism of nifedipine were studied in vitro and in situ. Erythromycin, clarithromycin or rokitamycin added to nifedipine did not inhibit the formation of metabolite, M-1,of nifedipine, whereas pretreatment with erythromycin or clarithromycin significantly (p<0.05) inhibited its formation. Only erythromycin significantly (p<0.05) inhibited the formation of M-2 from M-1. These observations agreed with the results obtained using an in situ rat intestinal loop technique. As assessed by the concentrations of nifedipine and M-2 in jugular and portal vein blood, the inhibition of nifedipine metabolism by erythromycin was greater after multiple doses than after a single dose.Moreover, our results suggest that rokitamycin is a less potent inhibitor of nifedipine metabolism.
- 公益社団法人日本薬学会の論文
- 1997-04-15
著者
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ARIMORI Kazuhiko
Department of Pharmacy, Miyazaki Medical College Hospital
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Nakamura Kazumi
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University
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Nakamura Kazumi
Department Of Pharmacy Kumamoto University Hospital
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Nakano Masahiro
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Tsuruta Satoshi
Department Of Pharmacy Kumamoto University Hospital
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Arimori Kazuhiko
Department Of Pharmacy Kumamoto University Hospital
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Nakano Masahiro
Deparment Of Physics Kyushu University
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Arimori Kazuhiko
Department Of Pharmacy Faculty Of Medicine University Of Miyazaki
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Arimori Kazuhiro
Department of Pharmacy, Kumamoto University Hospital
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