Enhanced Fecal Excretion of Bile Acids by a New Anion-Exchange Resin Possessing a Spacer Arm in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effect of a new polystyrene-based, strongly basic, anion-exchange resin possessing an ω-oxobutyl chain as a spacer arm on the fecal bile acid excretion was investigated in rats and compared with that of Dowex 1-X2,chemically equivalent to cholestyramine. The new resin did produce a significant rise in the total fecal bile acid excretion with its ingestion for a period of 4 weeks. Its promoting activity proved to be 2.0- and 1.8-fold more potent than that of Dowex 1-X2 at the 3rd and 4th week, respectively. These results suggest that the introduction of a spacer arm between the polymer backbone and a functional group would lead to an improvement in the in vivo adsorptive efficiency of the resin.
- 公益社団法人日本薬学会の論文
著者
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Haratake Mamoru
熊本大学医学部附属病院 薬剤
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Haratake Mamoru
Department Of Pharmacy Kumamoto University Hospital:faculty Of Pharmaceutical Sciences Kumamoto Univ
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NAKANO Masahiro
Department of Physics, Kyoto University
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HONDA Yoshiteru
Department of Pharmacy, Kumamoto University Hospital
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SUGII Atsushi
Department of Pharmacy, Kumamoto University Hospital
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Nakano Masahiro
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Sugii A
Kumamoto Univ. Kumamoto Jpn
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Honda Yoshiteru
Department Of Pharmacy Kumamoto University Hospital
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Honda Yoshiteru
Department Of Pharmacy Kumamoto University Hospital:faculty Of Pharmaceutical Sciences Kumamoto Univ
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Nakano Masahiro
Department Of Pharmacy Kumamoto University Hospital:faculty Of Pharmaceutical Sciences Kumamoto Univ
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Nakano Masahiro
Deparment Of Physics Kyushu University
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