Usefulness of Hydrophilic vs Lipophilic Statins After Acute Myocardial Infarction : Subanalysis of MUSASHI-AMI
スポンサーリンク
概要
- 論文の詳細を見る
Background Statins are widely used to reduce blood levels of low-density lipoprotein-cholesterol (LDL-C). Each statin has unique pharmacokinetic properties; lipophilicity is one such property and relates to tissue selectivity. Methods and Results The Multicenter Study for Aggressive Lipid-lowering Strategy by HMG-CoA Reductase Inhibitors in Patients with Acute Myocardial Infarction (MUSASHI-AMI) trial evaluated the effect of discretional statin treatment initiated within 96 h after onset of acute myocardial infarction (AMI) in Japanese patients. To clarify whether statin lipophilicity affects prognosis, a post hoc analysis of the MUSASHI-AMI database was performed. Patients who were assigned to receive statin were separated into 2 groups according to the lipophilicity of the statins they were administered: lipophilic statins (atorvastatin, fluvastatin, pitavastatin and simvastatin; LS group; n=131) or hydrophilic statins (pravastatin; HS group; n=110). There was no difference in baseline LDL-C concentrations between the 2 groups. Although LDL-C was decreased more potently in the LS than HS groups (-34% vs -19%; p=0.0069), acute coronary syndrome events tended to occur less frequently (3.6% vs 9.9%; p=0.0530) and the incidence of new Q-wave appearance in electrocardiogram was significantly lower (75% vs 89%; p=0.0056) in the HS than LS groups. Conclusions In normocholesterolemic Japanese patients after AMI, hydrophilic pravastatin could be superior to lipophilic statins at preventing new Q-wave appearance and reducing cardiovascular events.
- 社団法人日本循環器学会の論文
- 2007-08-20
著者
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Ogawa Hisao
Department of Cardiology, Kumamoto University
-
Kojima Sunao
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Ogata Yasuhiro
Division of Cardiology, Kumamoto Red-Cross Hospital
-
Kimura Kazuo
Department of Cardiorenal Medicine, Yokohama City University Graduate School of Medicien
-
Shimomura Hideki
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Sakamoto Tomohiro
Division Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center
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Ogata Yasuhiro
Japanese Acute Coronary Syndrome Study (jacss)
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Shimomura Hideki
Division Of Cardiology Fukuoka Tokusyukai Hospital
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Ogata Yasuhiro
Japanese Red Cross Kumamoto Hospital
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Shimomura Hideki
Fukuoka Tokusyuukai Hospital
-
Kamide Kei
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
-
Kojima Sunao
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto Uinversity
-
Kohagura Kentaro
琉球大学 第三内科
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KITAGAWA Akira
Department of Clinical Trial Management, Graduate School, International University of Health and Wel
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SAKAINO Naritsugu
Division of Cardiology, Amakusa Medical Center
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Sakamoto Tomohiro
Keio University School Of Medicine
-
Sato Takahiro
Division Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center
-
Sakaino Naritsugu
Kumamoto Intervention Conference Study
-
Ogata Yasuhiro
Division Of Cardiology Japan Red Cross Kumamoto Hospital
-
Shimomura Hideki
Division Of Cardiology Fukuoka Tokushukai Hospital
-
Satoh Toru
Division Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center
-
Sakamoto Tomohiro
Division Of Cardiology Cardiovascular Center Saiseikai Kumamoto Hospital
-
Sakaino Naritsugu
Division Of Cardiology Amakusa Medical Center
-
Ogawa Hisao
Department Cardiovascular Medicine Kumamoto University:division Of Intensive Care Unit Kumamoto Univ
-
Kitagawa Akira
Department Of Clinical Trial Management Graduate School International University Of Health And Welfa
-
Sakamoto Tomohiro
Cardiopulmonary Division School Of Medicine Keio University
-
Kimura Kazuo
Department Of Cardiology Other Hospitals
-
Kimura Kazuo
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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