Identification and Determination of Urinary and Biliary Metabolites of 2-Isopropylnaphthalene in Rats

概要

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Four unconjugated metabolites of 2-isopropylnaphthalene (2-IPN) were identified by thin-layer chromatography and gas-liquid chromatography (GLC) from the bile of rats receiving 2-IPN orally ; they were 2-(2-naphthyl) propionic acid, 2-(2-naphthyl)-2-propanol, 2-(2-naphthyl)-2-hydroxypropionic acid, and 2-(2-naphthyl)-1,2-propanediol, together with the unchanged compound. The presence of glucuronides of these four metabolites was also suggested by GLC of the extract obtained after hydrolysis by β-glucuronidase. In addition, quantitative determination of the metabolites indicated that the total urinary and biliary excretions of these metabolites in 24 h after administration were about 23% and about 18% of the dose, respectively, and that the urinary and biliary metabolite excretion patterns were the same.
公益社団法人日本薬学会の論文
1984-04-30