Chemistry of Tremorogenic Metabolites. I. Fumitremorgin A from Aspergillus fumigatus
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概要
- 論文の詳細を見る
Two new indolic metabolites, fumitremorgin A and B, were isolated from the fungus Aspergillus fumigatus. These two metabolites caused severe tremor and convulsion in experimental animals. The structure of fumitremorgin A, including the stereochemistry, was determined to be 1 mainly on the basis of the spectral data for the compound and some derivatives obtained from it. The stereochemical factors affecting the appearance of tremorogenic activity in fumitremorgin A and related compounds are discussed.
- 公益社団法人日本薬学会の論文
- 1980-01-25
著者
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藤本 治宏
Research Institute for Chemobiodynamics, Chiba University
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山崎 幹夫
Research Institute for Chemobiodynamics, Chiba University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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河崎 孝男
Research Institute For Chemobiodynamics Chiba University
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