Curcuma longa Extract Protects against Gastric Ulcers by Blocking H_2 Histamine Receptors(Pharmacology)
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概要
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Curcuma longa has been commonly used as a traditional remedy for a variety of symptoms such as inflammation, gastritis and gastric ulcer. When C. longa extract was administered per os to pylori-ligated rat stomachs, it reduced gastric acid secretion and protected against the formation of gastric mucosal lesions. We therefore tested whether C. longa extract inhibits gastric ulcers by blocking the H_2 histamine receptor. Dimaprit, a H_2 histamine receptor agonist, induced intracellular cAMP production in U937 and HL-60 promyelocytes. Pretreatment with C. longa extract significantly blocked dimaprit-induced cAMP production in a concentration dependent manner, but had no effect on the elevation of cAMP levels triggered by isoproterenol-induced β_2-adrenoceptor activation in U937 cells. To identify the active component (s) of C. longa extract, we sequentially fractionated it by extraction with ethyl acetate, n-butanol and water. We found that the ethyl acetate extract showed the most potent H_2R antagonistic effect against dimaprit-induced cAMP production. However, curcumin, a major component of C. longa extract, showed no H_2R blocking effect. C. longa ethanol extract and ethylacetate extract also blocked the binding of [^3H]-tiotidine to membrane receptors on HL-60 cells. These findings suggest that the extract from C. longa specifically inhibits gastric acid secretion by blocking H_2 histamine receptors in a competitive manner.
- 公益社団法人日本薬学会の論文
- 2005-12-01
著者
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Kim Sun
Division Of Information And Electronics Korea Institute Of Science And Technology
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Kim Kyong
Division of Information Display Engineering, Hanyang University
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BAEK Nam
Graduate School of Biotechnology and PMRC, Kyung Hee University
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Baek Nam
Graduate School Of Biotechnology & Plant Metabolism Research Center Kyung Hee University
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Kim Dong
Division of Maternal-Feta Medicine, Department of Obstetrics and Gynecology, College of Medicine Cat
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CHOI Bo
Division of Molecular and Life Science, SBD-NCRC, Pohang University of Science and Technology
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KIM Daeho
Department of Chemistry, Division of Molecular and Life Science, Pohang University of Science and Te
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KIM Mahn
Department of Chemistry, Division of Molecular and Life Science, Pohang University of Science and Te
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Kim Kyong
Division Of Molecular And Life Science Sbd-ncrc Pohang University Of Science And Technology
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Choi Bo
Division Of Molecular And Life Science Sbd-ncrc Pohang University Of Science And Technology
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Kim Dong
Division Of Electronic And Electrical Engineering Kyungnam University
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Kim Mahn
Department Of Chemistry Division Of Molecular And Life Science Pohang University Of Science And Tech
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Kim Daeho
Department Of Chemistry Division Of Molecular And Life Science Pohang University Of Science And Tech
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Kim Sun
Division Of Molecular And Life Science Sbd-ncrc Pohang University Of Science And Technology
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Kim Sun-hee
Division Of Bioscience And Bioinformatics College Of Natural Science Myongji University
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Kim Dong
Division Of Molecular And Life Science Sbd-ncrc Pohang University Of Science And Technology:division
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Kim Sun
Division Of Endocrinology And Metabolism Department Of Medicine Samsung Medical Center Sungkyunkwan University School Of Medicine
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Kim Dong-Chan
Division of Molecular and Life Science, SBD-NCRC, Pohang University of Science and Technology
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Choi Bo-Hwa
Division of Molecular and Life Science, SBD-NCRC, Pohang University of Science and Technology
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BAEK NAM
Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University
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