Effects of the Licorice Extract against Tumor Growth and Cisplatin-Induced Toxicity in a Mouse Xenograft Model of Colon Cancer(Pharmacology)
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概要
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Cisplatin is one of the most effective chemotherapeutic agents and plays a major role in the treatment of a variety of human solid tumors. However, its toxicity limits the clinical use. Recently, the administration of antioxidants has been suggested to protect against cisplatin-induced nephrotoxicity. The present study was designed to estimate the antitumor activity of the licorice extract alone and in combination with cisplatin, and its protective potential against cisplatin-induced toxicity in a mouse xenograft model. The administration of the licorice extract significantly inhibited tumor growth in BALB/C mice inoculated with CT 26 colon cancer cells. The combination of the licorice extract and cisplatin diminished the therapeutic efficacy of cisplatin but promoted considerably antitumor activity of the licorice extract. In mice with cisplatin treatment for 15 d, the serum levels of blood urea nitrogen and creatinine remarkably were increased by kidney damage, and the serum alanine aminotransferase and aspartate aminotransferase levels were elevated by liver damage. The administration of the licorice extract plus cisplatin recovered these functional indices in the kidney and liver to almost the control levels. In addition, the administration of the licorice extract significantly reduced the cisplatin-induced oxidative stress. Taken together, the administration of the licorice extract inhibits the growth of mouse colon carcinoma without any adverse effects, and reduces the cisplatin-induced toxicity. Therefore, the licorice extract may be a candidate for an anticancer and chemopreventive agent. However, cancer patients with cisplatin therapy should avoid the supplementation of the licorice extract.
- 公益社団法人日本薬学会の論文
- 2007-11-01
著者
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Lim Soon
Department of Food Science and Nutrition, Hallym University
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LEE Chang
Department of Oral Biology, Yonsei University College of Dentistry
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Park Kwang
Department Of Oral Biology Oral Cancer Research Institute Oral Science Research Institute
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PARK Jung
Department of East-West Medicine, Graduate School, Kyung Hee University
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Lim Soon
Dep. Of Food Sci. And Nutrition Hallym Univ.
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Lim Soon
韓国
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Lim Soon
Department Of Food Science And Nutrition Silver Biotechnology Research Center Hallym University
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Chung Won
韓国
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Chung Won
Department Of Oral Biology Oral Cancer Research Institute Oral Science Research Institute
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Lim Soon
Department Of Food Science And Nutrition Hallym University:regional Innovation Center Hallym Univers
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Park Jung
Department Of Food Science And Nutrition Silver Biotechnology Research Center Hallym University
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Chung Won
Depart. Of Physics Institute Of Basic Medical Science
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Lee Chang
Department Of Animal Science Utsunomiya University
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Lee Chang
Department Of Oral Biology Oral Cancer Research Institute Oral Science Research Institute
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Park Kwang
Department Of Microbiology College Of Medicine Korea University
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Park Jung
Department Of Chemistry Gyeongsang National University
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Park Jung
Department Electrical Engineering Busan National University
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Park Kwang
Department Of Chemical Engineering And Polymer Technology Institute Sungkyunkwan University
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Lee Chang
Departlnent Of Biology College Of Natural Sciences Kyungpook National University Korea
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Lim Soon
Department of Food and Nutrition, Hallym University
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