Discovery of Artemisinin-Glycolipid Hybrids as Anti-oral Cancer Agents

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概要

• 論文の詳細を見る

• Novel artemisinin-glycolipid hybrids were directly synthesized from 12β (C–C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro anticancer activity, particularly against the oral carcinoma cancer cell lines, respectively. The artemisinin-glycolipid hybrids, with effective concentrations under 20 μM, demonstrated better anticancer activity than either artemisinin or glycolipid alone and showed five times more anti-oral cancer activity than either cisplatin or paclitaxel.

著者

• Kim Minkyu

  Department Of Biomedical Engineering School Of Medicine Kyungpook National University

• Chung Won-yoon

  Department Of Oral Biology Yonsei University College Of Dentistry

• Park Kwang-kyun

  Department Of Oral Biology And Oral Cancer Research Center College Of Dentistry Yonsei University

• Ricci Jérémy

  Department of Chemistry, Yonsei University

• Jung Mankil

  Department of Chemistry, Yonsei University

• Park Kwang-Kyun

  Department of Oral Biology, College of Dentistry, Yonsei University

• RICCI Jeremy

  Department of Chemistry, Yonsei University

• Kim Minkyu

  Department of Chemistry, Yonsei University

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