Effective Isolation of Magnesium Lithospermate B and Its Inhibition of Aldose Reductase and Fibronectin on Mesangial Cell Line
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概要
- 論文の詳細を見る
We developed an effective isolation method of magnesium lithospermate B from Salviae miltiorrhizae Radix and found for the first time that magnesium lithospermate B shows strong in vitro inhibition (IC_<50>=0.04 μM) of aldose reductase (AR), 2.5 times than that of clinically used epalrestat (IC_<50>=0.1 μM) and accumulation of fibronectin dose dependantly.
- 社団法人日本薬学会の論文
- 2002-08-01
著者
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Lee Hyun
Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan Univ
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Lee Hyun
Division Of Endocrinology And Department Of Internal Medicine College Of Medicine Yonsei University
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JUNG Mankil
Department of Chemisty, Yonsei University
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AHN Chul
Division of Endocrinology and Department of Internal Medicine, College of Medicine, Yonsei Universit
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PARK Whuijung
Department of Chemisty, Yonsei University
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CHOI Sunhee
Department of Chemisty, Yonsei University
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KIM Hanjo
Department of Chemisty, Yonsei University
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CHO Donghak
Department of Chemisty, Yonsei University
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LEE Geun
Department of Biochemistry, Yonsei University
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LI Hai-Ri
Division of Endocrinology and Department of Internal Medicine, College of Medicine, Yonsei Universit
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Ahn Chul
Division Of Endocrinology And Department Of Internal Medicine College Of Medicine Yonsei University
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Li Hai-ri
Division Of Endocrinology And Department Of Internal Medicine College Of Medicine Yonsei University
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Kim Hanjo
Department Of Chemisty Yonsei University
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Choi Sunhee
Department Of Chemisty Yonsei University
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Cho Donghak
Department Of Chemisty Yonsei University
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Jung Mankil
Department Of Chemisty Yonsei University
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Park Whuijung
Department Of Chemisty Yonsei University
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Lee Geun
Department Of Biochemistry Yonsei University
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Lee Hyun
Division Of Cardiology Department Of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan Univers
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Jung Mankil
Department of Chemistry, Yonsei University
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- Effective Isolation of Magnesium Lithospermate B and Its Inhibition of Aldose Reductase and Fibronectin on Mesangial Cell Line
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