Cyclooxygenase-2 Inhibitory Phenylbutenoids from the Rhizomes of Zingiber cassumunar
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概要
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Phenylbutenoids 1-6 isolated previously from the CHCl_3 extracts of the rhizomes of Zingiber cassumunar, were evaluated for their cyclooxygenase-2 (COX-2) inhibitory activity along with a new isolate, 7 from the n-BuOH extracts of this plant. The COX-2 inhibitory assay was performed by measuring prostaglandin E_2 production in lipopolysaccharide-stimulated mouse macrophage RAW 264.7 cells. Two phenylbutenoid dimers, 1 and 2, exhibited considerable activity with IC_<50> values of 2.71 and 3.64μM. Two phenylbutenoid monomers, 3 and 4, showed moderate activity (IC_<50> 14.97, 20.68μM, respectively). The other three phenylbutenoids, 5-7, were found to be inactive. Compound 7 was elucidated as a new phenylbutenoid glycoside, namely, (E)-4-(3, 4-dimethoxy-phenyl)but-3-en-1-O-β-D-glucopyranoside by spectral analysis including various 1D- and 2D-NMR experiments.
- 社団法人日本薬学会の論文
- 2005-11-01
著者
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Lee Sang
College Of Industrial Science Chung-ang University
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Kim Moon
College Of Pharmacy Ewha Womans University
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Han Ah-reum
韓国
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Han Ah-reum
College Of Pharmacy And Center For Cell Signaling & Drug Discovery Research Ewha Womans Universi
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Lee Sang
Coll. Of Pharmacy Ewha Womans Univ.
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HAN Ah
College of Pharmacy, Ewha Womans University
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JEONG Yeon
College of Pharmacy, Ewha Womans University
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SEO Eun
College of Pharmacy, Ewha Womans University
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Jeong Yeon
College Of Pharmacy Sookmyung Women's University
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Seo Eun-kyoung
Natural Product Chemistry Laboratory College Of Pharmacy And The Center For Cell Signaling & Dru
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Han Ah
College Of Pharmacy And The Center For Cell Signaling & Drug Discovery Research Ewha Womans Univ
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Seo Eun
Natural Product Chemistry Laboratory College Of Pharmacy & The Center For Cell Signaling And Dru
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Lee Sang
College Of Agriculture And Life Sciences Kyungpook National University
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Seo Eun
College Of Pharmacy And The Center For Cell Signaling & Drug Discovery Research Ewha Womans Univ
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Jeong Yeon
College Of Pharmacy Ewha Womans University
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Han Ah-reum
Dep. Of Physiology Coll. Of Oriental Medicine Kyung Hee Univ.
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Kim Moon-Sun
College of Pharmacy, Ewha Womans University
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