Antiinflammatory Activity of α-Hederin Methyl Ester from the Alkaline Hydrolysate of the Butanol Fraction of Kalopanax pictus Bark Extract
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概要
- 論文の詳細を見る
Three antiinflammatory saponin components were isolated from the alkaline hydrolysate of a butanol-soluble portion of Kalopanax pictus bark extract through an in vivo activity-guided fractionation procedure. The hydrolysate showed inhibition of adjuvant induced arthritis in rats. After further fractionation, the ethyl acetate fraction exhibited antiarthritic activity, which resulted in the isolation of α-hederin, α-hederin methyl ester, and kalopanaxsaponin I. All compounds showed inhibition of vascular permeability in mice, but only α-hederin methyl ester showed anticarrageenan activity in rats and antiarthritic activity in rats and mice.
- 公益社団法人日本薬学会の論文
- 2003-04-01
著者
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Kim Yeong
Natural Products Research Institute College Of Pharmacy Seoul National University
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Kim Yeong
Natural Products Res. Inst. Coll. Of Pharmacy Seoul National Univ.
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Cheong Choon
韓国
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Lee Eun
Natural Products Research Institute College Of Pharmacy Seoul National University
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Li D
Natural Products Research Institute Seoul National University
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Li Da
Natural Products Research Institute Seoul National University
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JEONG Choon
College of Pharmacy, Duksung Women's University
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HYUN Jin
Natural Products Research Institute, Seoul National University
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Hyun J
Natural Products Research Institute Seoul National University
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Lee E
Seoul National Univ. Seoul Kor
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Jeong Choon
College Of Pharmacy Duksung Women 's University
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Lee Eun
Natural Products Research Center Korea Institute Of Science And Technology (kist) Gangneung Institut
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Hyun Jin
Natural Products Research Institute Seoul National University
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