Effects of Low Molecular Weight Chondroitin Sulfate on Type II Collagen-Induced Arthritis in DBA/1J Mice(Pharmacology)
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概要
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In order to evaluate the improvement in the treatment of chronic arthritis, we investigated chondroitin sulfate depolymerization product (low molecular weight chondroitin sulfate, LMWCS) and intact chondroitinsul fate (CS) in vitro and in vivo. LMWCS was prepared by a chemical depolymerization process induced by hydrogen peroxide in the presence of copper salts. LMWCS (300 mg/kg) and CS (1200 mg/kg) were orally administered to DBA/1J mice once daily for 14d prior to initial immunization with type II collagen. Their elastase activities and the production of cytokines in sera were examined on type II collagen-induced arthritis in DBA/1J mice. We also compared the paracellular transport of LMWCS and CS across Caco-2 cell monolayers and examined the inhibitory effects on elastase activities. LMWCS inhibited elastase activity slightly, but CS did not show inhibition. Hind paw edema was significantly decreased by LMWCS treatment. Levels of anti-type II collagen antibody and tumor necrosis factor-alpha (TNF-α) in sera were also reduced by LMWCS treatment but not in case of CS, although no significant difference was observed between LMWCS and CS on interleukin-6 (IL-6) induction. The LMWCS preparation showed preventive effects on the type II collagen-induced arthritis in DBA/1J mice and better permeability through Caco-2 cells.
- 公益社団法人日本薬学会の論文
- 2004-01-01
著者
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Kim Yeong
Natural Products Research Institute College Of Pharmacy Seoul National University
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Kim Yeong
Natural Products Res. Inst. Coll. Of Pharmacy Seoul National Univ.
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Cheong Choon
韓国
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Cho So
Natural Products Research Institute College Of Pharmacy Seoul National University:division Of Herbal
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Cho S
Seoul National Univ. Seoul Kor
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Choi Don
Division Of Herbal Medicine Standardization Korea Food And Drug Administration
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Sim Joon
Natural Products Research Institute College Of Pharmacy Seoul National University:national Institute
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Toida Toshihiko
Graduate School of Pharmaceutical Sciences, Chiba University
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JEONG Choon
College of Pharmacy, Duksung Women's University
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TOIDA Toshihiko
Department of Analytical Chemistry, Meiji College of Pharmacy
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SIM Joon-Soo
Natural Products Research Institute, College of Pharmacy, Seoul National University
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CHANG Seung
Division of Herbal Medicine Standardization, Korea Food and Drug Administration
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Jeong Choon
College Of Pharmacy Duksung Women 's University
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Toida T
Department Ofbioanalytical Chemistry Graduate School Of Pharmaceutical Sciences Chiba University
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