Effect of Cardiac Rehabilitation and Statin Treatment on Anti-HSP Antibody Titers in Patients With Coronary Artery Disease After Percutaneous Coronary Intervention

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概要

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• Accumulating evidence suggests that higher antibody titers to heat shock proteins (HSPs) are associated with the development and severity of atherosclerosis. The aim of this study was to evaluate the impact of cardiac rehabilitation therapy (CRT) or stain treatment (STT) or a combination of both (COM) on anti-HSP antibodies in patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI). Clinical evaluation of subjects was performed both at the commencement and completion of the 14 weeks of treatment. CRT consisted of a supervised 6 weeks of exercise following hospital discharge and 8 weeks of home stay exercise. Patients assigned to statin therapy were treated with 80 mg per day of fluvastatin. Blood samples from 39 patients were analyzed for antibodies to HSP60 and HSP70 by ELISA. Biochemical parameters, including lipids, high-sensitivity C reactive protein (hsCRP), and interleukin-6 (IL-6), were also analyzed. We found that CRT and COM reduced antibody titers to HSP60 and HSP70 in CAD patients (by 3.79 and 10.00% of anti-HSP60, and by 5.74 and 3.45% of anti-HSP70, respectively) but statin treatment reduced only antibody titers to HSP70 (by 3.83%). There was a significant correlation between antibody titers to HSP60 versus HSP70. Considering the fact that antibody titers to HSPs are associated with the autoimmune process in CAD, CRT and COM have greater effects on reduction in autoimmune reaction after PCI than statin treatment. This reduction was accompanied by greater improvements in blood biochemical variables, such as lipids, hsCRP, and IL-6 after CRT and COM.

著者

• Shin Young-oh

  Department Of Sports Medicine Korea National Sport University

• Yang Hun-mo

  Department Of Pediatnics(divesion Of Pediatric Endocrinology) Yale University School Of Medicine

• Min Young-ki

  Department Of Pediatnics(divesion Of Pediatric Endocrinology) Yale University School Of Medicine

• Kim Young-joo

  Department Of Agricultural Engineering Chonbuk National University

• Bae Jun-sang

  Department Of Nuclear Medicine Samsung Medical Center Sungkyunkwan University School Of Medicine

• Kim Chul

  Department Of Animal Resources Technology Jinju National University

• Lee Jeong-Beom

  Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan

• Othman Timothy

  Princeton Research Center, Huntingdon Life Sciences

• Kim Jung-Kyu

  Department of Leisure, Sports, Kangwon National University

• Ahn Jae-Ki

  Department of Rehabilitation Medicine, College of Medicine, Inje University

• Bang In-Keol

  Department of Rehabilitation Medicine, College of Medicine, Inje University

• Lee Byoung-Kwon

  Department of Internal Medicine, College of Medicine, Inje University

• Min Young-Ki

  Department of Physiology, College of Medicine, Soonchunhyang University

• Shin Young-Oh

  Department of Physiology, College of Medicine, Soonchunhyang University

• Kim Young-Joo

  Department of Rehabilitation Medicine, College of Medicine, Inje University

• Bae Jun-Sang

  Department of Physiology, College of Medicine, Soonchunhyang University

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