Amelioration of Oxygen and Glucose Deprivation-Induced Neuronal Death by Chloroform Fraction of Bay Leaves (Laurus nobilis)

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概要

• 論文の詳細を見る

• The purpose of this study was to determine whether the Laurus nobilis chloroform fraction (LNCF) protects against cerebral ischemia neuronal damage. Human neuroblastoma SH-SY5Y cells and brain slices from rats were subjected to oxygen and glucose deprivation (OGD), followed by reoxgenation with and without LNCF. The viabilities of SH-SY5Y cells and brain slices from the rats were 58.5±4.9% and 79.7±5.9% in the group subjected to OGD, and 80.4±0.4% and 97.2±1.9% at 4 μg/ml of LNCF, respectively. LNCF also significantly inhibited death-associated protein kinase (DAPK) dephosphorylation. Pretreatment with LNCF at 4 mg/kg significantly decreased infarct size by 79% of vehicle control in the middle cerebral artery occlusion (MCAO) in vivo model. LNCF is a neuroprotective drug candidate against cerebral ischemia neuronal damage.

• 社団法人 日本農芸化学会の論文

著者

• Oh Ki-bong

  School Of Agricultural Biotechnology Seoul National University

• MAR Woongchon

  Natural Products Research Institute, College of Pharmacy, Seoul National University

• SHIN Jongheon

  Natural Products Research Institute, College of Pharmacy, Seoul National University

• Cho Eun-Young

  Natural Product Research Institute, College of Pharmacy, Seoul National University

• Lee Sung-Jin

  Department of Animal Biotechnology, Kangwon National University

• Nam Kung-Woo

  Natural Product Research Institute, College of Pharmacy, Seoul National University

• KIM Kyeong

  College of Pharmacy, Kangwon National University

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