Bithiazole Metabolites from the Myxobacterium Myxococcus fulvus
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概要
- 論文の詳細を見る
Two new bithiazole metabolites (3, 4) along with the previously reported compounds (1, 2) were isolated from the culture broth of the gliding bacterium Myxococcus fulvus collected from a Korean soil. The structures of these compounds were determined to be analogous to myxothiazole A on the basis of combined spectroscopic analyses. The new compounds exhibited significant cytotoxicity and moderate antifungal activity against the mouse fibloblast cell-line L929 and Candida albicans, respectively. These data were consistent with the previous finding that the bioactivity of myxothiazoles was highly dependent on the presence of terminal methoxy enol functionality.
- 社団法人日本薬学会の論文
- 2007-03-01
著者
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Ahn Jong-woong
Division Of Marine Environment & Bioscience College Of Ocean Science And Technology Korea Mariti
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Oh Ki-bong
School Of Agricultural Biotechnology Seoul National University
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SHIN Jongheon
Natural Products Research Institute, College of Pharmacy, Seoul National University
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JANG Kyoung
Natural Products Research Institute, College of Pharmacy, Seoul National University
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YANG Hyeong-Cheol
Department of Dental Biomaterials Science, College of Dentistry, Seoul National University
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LEE Hyi-Seung
Marine Natural Products Laboratory, Korea Ocean Research & Development Institute
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Oh Ki-bong
School Of Agricultural Biotechnology Seoul National Univ.
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Jang Kyoung
Natural Products Research Institute College Of Pharmacy Seoul National University
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Lee Hyi-seung
Marine Natural Products Lab. Korea Ocean Res. & Dev. Inst.
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Shin Jongheon
Natural Product Res. Inst. Coll. Of Pharmacy Seoul National Univ.
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Yang Hyeong-cheol
Department Of Dental Biomaterials Science College Of Dentistry Seoul National University
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