Depigmentation of Melanocytes by (2Z,8Z)-Matricaria Acid Methyl Ester Isolated from Erigeron breviscapus

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概要

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• To discover an active skin depigmenting agent, we isolated a novel inhibitor of melanin biosynthesis from the methanol extract of Erigeron breviscapus using a bioactivity-guided fractionation and identified it as (2Z,8Z)-matricaria acid methyl ester by means of spectroscopic analysis. The compound showed strong whitening activity in melan-a cell. Compared with arbutin (IC50=4.0 mM) as a positive control, the depigmentation IC50 value for (2Z,8Z)-matricaria acid methyl ester was 25.4 μM in B16F10 melanoma cell. Moreover, its inhibitory effect on tyrosinase, the key enzyme of melanogenesis, was examined by in vivo and in vitro tyrosinase assay and Western blot. The results indicate that (2Z,8Z)-matricaria acid methyl ester isolated from Erigeron breviscapus is a promising compound that could be useful for treating hyper-pigmentation as skin-whitening agents.

• 公益社団法人　日本薬学会の論文

著者

• LEE Nam

  Department of Chemistry, Korea Military Academy

• Lee Nam

  Department Of Biochemistry Dongguk University

• KIM Hae

  Department of Computer Science and Engineering, Sejong University

• KIM EUN-KI

  Department of Biological Engineering, Institute of Biotechnology, Inha University

• Kim Eun-ki

  Department Of Biological Engineering Institute Of Biotechnology Inha University

• Luo Lian

  Department of Biological Engineering, National Lab of Skin Bioactive Material, Inha University

• Nguyen Dung

  Department of Biological Engineering, National Lab of Skin Bioactive Material, Inha University

• Lee Hyang-Bok

  Department of Biological Engineering, National Lab of Skin Bioactive Material, Inha University

• Kim Hae

  Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University

• Kim Eun-Ki

  Department of Biological Engineering, National Lab of Skin Bioactive Material, Inha University

• Lee Nam

  Department of Chemistry, College of Natural Sciences, Cheju National University

• Kim Hae

  Department of Biological Engineering, National Lab of Skin Bioactive Material, Inha University

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