Tissue Distribution of Sialoglycopeptide-Bearing Liposmones in Rats
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概要
- 論文の詳細を見る
The effect of sialoglycopeptide (GP) derived from fetuin on the tissue distribution of [^3H]inulin-containing small unilamellar vesicles (SUV) was examined in rats. As the amount the GP covalently bound to the SUV was increased, the liver uptake of GP-SUV decreased, while their level in the blood increased. No significant difference in the [^3H]inulin levels in heart, kidney, lung and spleen was observed after administration of control or GP-SUVs. These results suggest that surface modification of SUV with fetuin GP selictively alters their hepatic uptake. This may be a usuful technique for designing liposomes with a long circulation time.
- 公益社団法人日本薬学会の論文
- 1988-10-25
著者
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芳賀 信
東京理科大学薬学部
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吉田 雅人
(present Address)planning Department R & D Division Pharmaceuticals Group Nippon Kayaku Co. Ltd.
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芳賀 信
東京理大・薬
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加藤 百合子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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芳賀 信
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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芳賀 信
Faculty Of Pharmaceutical Sciences Sciences University Of Tokyo
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斉藤 勝実
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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安藤 純一
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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