O/W型軟膏中におけるプレドニゾロンの結晶変化におよぼす高級アルコールの影響

概要

論文の詳細を見る
The influence of ointment composition and storage temperature on the conversion of the prednisolone anhydrous form (A-PD) to its hydrated form (C-PD) in O/W type ointment was studied using an X-ray diffractmeter and a polarizing microscope. When either stearyl alcohol or cetyl alcohol alone was added to the ointment, A-PD was easily converted into C-PD, especially at low storage temperature. On the other hand, when a mixture of alcohols was used in a proper ratio, the conversion of A-PD to C-PD was retarded. Particularly, when stearyl alcohol and cetyl alcohol were mixed in the ratio of approximately 2 : 3,A-PD remained most stable. When O/W type ointment, including A-PD, was stored at high temperature (37°) for a long time and then moved to a low temperature (5°) for storage, it was not easy to convert into C-PD. These results were due to the property of three polymorphisms (α, β, and γ) of long-chain alcohols. The ointment structure containing the α-form was stable enough to stabilize A-PD, while that containing the β- or γ-form was less stable.
公益社団法人日本薬学会の論文
1979-11-25