Application of Synthetic Alkyl Glycoside Vesicles as Drug Carriers. I. Preparation and Physical Properties

概要

論文の詳細を見る
It was observed that alkyl glycosides formed lamellar vesicles like phosphatidylcholine vesicles (liposomes), and the application of these vesicles as drug carriers was attempted. Various alkyl glycosides were synthesized and vesicles were prepared with these glycosides. The encapsulation capacity of the vesicles was examined in relation to alkyl chain length, sugar moiety, and lipid composition. The glucosides of myristyl, cetyl, and stearyl alcohols formed vesicles, but those of lauryl, decyl, and octyl alcohols did not. The vesicles of glucoside, galactoside, and mannoside showed fairly good encapsulation capacity but those of lactoside showed low capacity. An appropriate ratio of glycoside, cholesterol, and dicetylphosphate is an important factor for the formation of these vesicles, especially with regard to dicetylphosphate. The alkyl glycoside vesicles show longer lives on stage in an ampule at 20℃ than phosphatidylcholine vesicles. The stability in plasma was also examined. The glycoside vesicles showed rapid release of about 40% of the aqueous contents, but after that, they showed outstanding stability for 48h in plasma at 37℃. On the other hand, phosphatidylcholine vesicles showed rapid release of only about 30%, but they disintegrated gradually and showed low encapsulation capacity (about 20%) after 48h. The present results suggest that the application of alkyl glycoside vesicles as drug carriers may be feasible.
公益社団法人日本薬学会の論文
1985-02-25

Application of Synthetic Alkyl Glycoside Vesicles as Drug Carriers. I. Preparation and Physical Properties

スポンサーリンク

概要

著者

関連論文

スポンサーリンク