New Polymorphic Forms of Phenobarbital
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概要
- 論文の詳細を見る
Two new polymorphic forms, form II-Ba and form III-Cy, were obtained by recrystallization of phenobarbital in the presence of a small quantity of barbital or cyclobarbital, respectively. The two forms could be discriminated by X-ray diffraction or infrared (IR) absorption measurements. The transition temperature and the heat of transition between form II-Ba and form II, and between form III-Cy and form II were determined to be 84℃ and 0.23 kcal/mol, and 44℃ and 0.68 kcal/mol, respectively, by solubility measurements. The dissolution rate of form II-Ba was higher than that of form II, whereas the dissolution rate of form III-Cy was lower than that or form II.
- 公益社団法人日本薬学会の論文
- 1984-10-25
著者
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加藤 百合子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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岡本 由美
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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永沢 佐世子
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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石原 伊知子
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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石原 伊知子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
永沢 佐世子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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岡本 由美
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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