溶解補助剤の研究(第6報) グリコール類およびその誘導体と水との混液中アスコルビン酸の安定性について

概要

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The relation between oxidation rate of ascorbic acid and amount of oxygen dissolved in aqueous solutions of various solubilizing agents was examined. The oxidation rate of ascorbic acid was determined by the Warburg apparatus. In aqueous solutions of ethylene glycol, diethylene glycol, and triethylene glycol, having a hydrophilic group, the amount of dissolved oxygen and the oxidation rate of ascorbic acid were found to decrease with increasing concentration of these agents. In contrast, aqueous solutions of Cellosolve, isopropyl-Cellosolve, butyl-Cellosolve, methyl-Carbitol, Carbitol, butyl-Carbitol, dipropylene glycol, 1-methoxy-2-propanol, and hexylene glycol, having both hydrophilic and hydrophobic groups, showed a minimum point in the amount of dissolved oxygen and the oxidation rate of ascorbic acid. These experimental results indicate that these solubilizing agents undergo association in these mixtures at the minimum concentration, decrease the ability of the solution to dissolve or diffuse oxygen at this concentration, and this is probably the reason why there is a maximum in stability of ascorbic acid at this concentration.
公益社団法人日本薬学会の論文
1976-02-25