Relationship between Polymorphism and Bioavailability of Amobarbital in the Rabbit
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概要
- 論文の詳細を見る
The effect of the polymorphic form of amobarbital on its bioavailability was examined by measurement of the dissolution rate and in vivo absorption of two forms (Form I and Form II). The dissolution rate of Form II was faster than that of Form I. In in vivo absorption experiments using rabbits, two crystal forms of amobarbital were administered orally and the resulting blood level-time curves were compared with the dissolution rates. It appeared that the polymorphic form of the drug appreciably affected the absorption process from the digestive tract. Hydroxyamobarbital was confirmed to be the main metabolite of amobarbital.
- 公益社団法人日本薬学会の論文
- 1981-01-25
著者
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加藤 百合子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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加藤 百合子
Japan and Faculty of Pharmaceutical Sciences, Science University of Tokyo
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纐纈 眞弓
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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加藤 百合子
Japan And Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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纐纈 眞弓
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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