Solubility of a New Polymorph of Phenobarbital obtained by Crystallization in the Presence of Phenytoin
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概要
- 論文の詳細を見る
Physicochemical properties of some polymorphs of phenobarbital were studied. A new polymorph, form III-Ph, with a slightly changed crystal habit was obtained by addition of phenytoin at the time of recrystallization. The transition temperature and the heat of transition between form III-Ph and form III, and between form III and form II were determined to be 46℃ and 0.201 kcal/mol, and 77℃ and 0.404 kcal/mol, respectively, by solubility measurement. As the dissolution rates of form III-Ph and form III were higher than that of form II, they are expected to show better bioavailability than form II.
- 公益社団法人日本薬学会の論文
- 1981-11-25
著者
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加藤 百合子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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岡本 由美
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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永沢 佐世子
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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植木 智子
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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永沢 佐世子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
岡本 由美
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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植木 智子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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