Effects of Phenylbutazone Analogues on the Plasma Concentration and Renal Excretion of Salicylate and Its Metabolites in Rabbits
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概要
- 論文の詳細を見る
Rabbits were intravenously coadministered with salicylate and each of various phenylbutazone analogues (oxyphenbutazone, γ-hydroxyphenylbutazone and ketophenylbutazone). After the drug administration, concentrations of salicylate and its metabolites in the plasma and in the urine were determined by using the GLC method. Salicylate elimination from the plasma was suppressed by oxyphenbutazone and ketophenylbutazone, but was not suppressed by γ-hydroxyphenylbutazone. The renal excretion of salicylate was markedly inhibited by each of the phenylbutazone analogues and the amount of salicylurate excreted was relatively increased, whereas that of salicyl glucuronides was insignificantly affected. Phenylbutazone itself slightly depressed the renal excretion of salicylurate.
- 公益社団法人日本薬学会の論文
- 1982-01-25
著者
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加藤 百合子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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加藤 百合子
Japan and Faculty of Pharmaceutical Sciences, Science University of Tokyo
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深沢 一也
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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西田 元女
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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市田 良平
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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加藤 百合子
Japan And Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
深沢 一也
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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西田 元女
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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市田 良平
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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