Studies on Tetrahydroisoquinolines. XXIV. A Synthesis of Dibenzo [c, f]-1-azabicyclo [3.3.1] nonanes and Dibenzo [d, g]-1-azabicyclo [4.3.1] decanes
スポンサーリンク
概要
- 論文の詳細を見る
Treatment of the N-benzyl p-quinol acetates 2a and 2b with trifluoroacetic acid gave dibenzo [c, f]-1-azabicyclo [3.3.1] nonanes (3a and 3b) in good yields. The homologs 3c, 3d, and 3e were similarly prepared from the N-phenethyl p-quinol acetates 2c, 2d, and 2e, respectively. On the other hand, the o-quinol acetate (17), obtained from the tetrahydroisoquinolin-6-ol (9) by lead tetraacetate oxidation, was rearranged to the 4-acetoxy derivative (18). Acid treatment of 18 induced cyclization to construct the same skeleton as that of 3a.
- 公益社団法人日本薬学会の論文
- 1985-07-25
著者
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星野 修
東京理科大学薬学部
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原 博
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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原 博
東京理科大学薬学部
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星野 修
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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梅澤 文輔
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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梅澤 文輔
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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原 博
東京理大 薬
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星野 修
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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