Synthesis of Sceletium and Amaryllidaceae Alkaloids, (±)-Mesembrine and (±)-Dihydromaritidine, (±)-Epidihydromaritidine, (±)-Elwesine, and (±)-Epielwesine(Organic,Chemical)

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概要

• 論文の詳細を見る

• The aikylation of 2-arylcyclohexanones(12b and 6) with alkyl halides or acrylonitriie and 50% aq. sodium hydroxide in the presence of a phase-transfer catalyst(18-crown-6) was found to give readily 2-alkyl-2-arylcyclohexanones(14 and 16) in fair to good yields. Furthermore, 2-allyl-2-aryl-5,5-ethylenedioxycyclohexanone(16a or 16b) was coverted into (±)-mesenibrine (1), (±)-dihydromaritidine(4a), and (±)-epidihydromaritidine (5a) or (±)-elwesine(dihydrocrinine)(4b) and (±)-epielwesine(5b), respectively, via 5,5-ethylenedioxy-2-formylmethyl-2-(3',4'-dimethoxy- or 3',4'-methylenedioxyphenyl)cyclohexyl acetate(20a or 20b).

• 公益社団法人日本薬学会の論文
• 1987-07-25

著者

• 星野 修

  東京理科大学薬学部

• 星野 修

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 梅澤 文輔

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 沢木 正平

  東京理科大薬

• 梅澤 文輔

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 小野寺 章

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 沢木 正平

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 島村 直巳

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 島村 直巳

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 星野 修

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

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