Studies on Tetrahydroisoquinolines. IV. Synthesis of 4-Alkyl (phenyl) amino-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolines

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概要

• 論文の詳細を見る

• Reaction of 4,7-diacetate (I) in a variety of aqueous amine solution was found to give the corresponding 4-alkylamino derivatives (Va-e or Vg-1) in good yield. In the case of aniline, however, the presence of potassium hydroxide was always required. Similar reaction with aqueous semicarbazide or thiosemicarbazide solution containing potassium carbonate or hydroxide afforded the corresponding 4-hydrazino derivatives (Vm or Vn) in good yield.

• 公益社団法人日本薬学会の論文
• 1971-10-25

著者

• 梅澤 文輔

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 星野 修

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 山梨 安弘

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

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