A Novel Synthesis of Aporphine Alkaloids via o-Quinol Acetates
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概要
- 論文の詳細を見る
Lead tetraacetate oxidation of 1-(3', 4'-dimethoxy- or 3', 4'-methylenedioxy-benzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (1a or 1b) in CH_2Cl_2 was found to give quantitatively a diastereomeric mixture (1 : 1) of an o-quinol acetate (2a or 2b), treatment of which with Ac_2O-conc. H_2SO_4 at room temperature led to (±)-O-acetyl-predicentrine (5a) or -isodomesticine (5b). Furthermore, hydrolysis of 5a or 5b with 1.7% KOH-MeOH afforded (±)-predicentrine (6a) or (±)-isodomesticine (6b).
- 公益社団法人日本薬学会の論文
- 1978-12-25
著者
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星野 修
東京理科大学薬学部
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星野 修
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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梅澤 文輔
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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梅澤 文輔
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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大谷 実
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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大谷 実
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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星野 修
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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