Medium-Membered Ring Ketone Synsthesis. Synthesis of Oxa- and Aza-cyclooctanone Derivatives

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概要

• 論文の詳細を見る

• As a model study on the synthesis of natural products possessing an eight-membered cyclic ether or amine framework such as laurencin (1) and FR900482 (6), two kinds of 2-benzyl oxacyclooctanones (7 and 8) and 2-methyl azacyclooctanones (9 and 10) were synthesized from the corresponding twelve-membered lactam sulfoxides (49-52) by applying our general method for medium-ring ketone synthesis. The corresponding lactam sulfides were readily prepared from the linear ω-tosyl carboxylic acids containing on oxygen atom (11 and 12) or methylcarbamate group (13 and 14) by condensation with 2-cyanoethyl 2-N-methylaminophenyl sulfide followed by alkylation.

• 公益社団法人日本薬学会の論文
• 1992-03-25

著者

• 小林 省吾

  Department Of Engineering Yokohama Natunal University

• 大石 武

  Faculty Of Engineering Yokohama National University:(present Address)meiji College Of Pharmacy

• 大石 武

  理研:(現)明治薬科大学

• 大塚 晏央

  Department of Engineering, Yokohama Natunal University

• 節原 謙一

  Department of Engineering, Yokohama Natunal University

• 河村 健一

  Department of Engineering, Yokohama Natunal University

• 飯森 隆昌

  Department of Engineering, Yokohama Natunal University

• 大石 武

  Department of Engineering, Yokohama Natunal University

• 大塚 晏央

  Faculty Of Engineering Yokohama National University:(present Address)pharmaceutical Research Center

• 河村 健一

  Department Of Engineering Yokohama Natunal University

• 飯森 隆昌

  Faculty Of Engineering Yokohama National University:(present Address)faculty Of Pharmaceutical Scien

• 節原 謙一

  Department Of Engineering Yokohama Natunal University

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