The Synthesis of 3-Spirooxindole Derivatives. VII. Total Synthesis of Alkaloids (±)-Rhynchophylline and (±)-Isorhynchophylline
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概要
- 論文の詳細を見る
The total synthesis of (±)-rhynchophylline (Ia) and (±)-isorhynchophylline (Ib) which are oxindole alkaloids of Uncaria rhynchophylla MIQ (Ourouparia rhynchophylla MATSUM), has been completed through eight stages starting from the condensation of 2-hydroxytryptamine hydrochloride (III) with ethyl sodium formyl acetate (IV). The success in the first-stage condensation is significant since ethyl sodium formyl acetate (IV) is rather unstable and has not been existent as the liberated ester. The sterostructures of the intermediates are discussed and mostly assigned.
- 公益社団法人日本薬学会の論文
- 1975-11-25
著者
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大石 武
Faculty Of Engineering Yokohama National University:(present Address)meiji College Of Pharmacy
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瀬戸 正彦
Faculty of Pharmaceutical Sciences, Hokkaido University
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伴 義雄
東邦大・薬
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伴 義雄
Faculty Of Pharmaceutical Sciences Hokkaido University
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大石 武
北大・薬:(現)理化学研究所
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瀬戸 正彦
Faculty Of Pharmaceutical Sciences Hokkaido University:(present Addresses)organic Chemistry Research
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