The Use of Microorganisms in Organic Synthesis. II. Microbiological Asymmetric Reduction of 2-Methyl-3-oxosuccinates
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概要
- 論文の詳細を見る
In order to synthesize four optically active methyl 2-methylmalates (10-13), microbiological asymmetric reduction of the corresponding dimethyl 2-methyl-3-oxosuccinate (9) was carried out. The β-keto diester 9 was found to be reduced by fermenting baker's yeast (Saccharomyces cerevisiae) and Candida albicans to afford a mixture of the (2R, 3R)-isomer 10 and the (2S, 3R)-isomer 11. Although the optical purity of 10 produced by Candida albicans was reasonably high (95% e.e.), optical yields of other products were unexpectedly low. However, identification of the four possible isomers 14-17 was found to be easily carried out by means of nuclear magnetic resonance spectroscopy.
- 公益社団法人日本薬学会の論文
- 1983-12-25
著者
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堀越 弘毅
Laboratory Of Bacteriology And Ecology The Institute Of Physical And Chemical Research (riken Instit
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秋田 弘幸
School Of Pharmaceutical Science Toho University
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秋田 弘幸
理化学研究所
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越地 弘子
Synthetic Organic Chemistry Laboratory The Institute Of Physical And Chemical Research (riken Instit
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大石 武
Synthetic Organic Chemistry Laboratory, The Institute of Physical and Chemical Research (Riken Insti
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古市 昭也
Synthetic Organic Chemistry Laboratory The Institute Of Physical And Chemical Research (riken Instit
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