Preparation of Chiral, Highly Functionalized Cyclopentenones
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概要
- 論文の詳細を見る
During a detailed examination on the cyclization of 1,4-diketones to cyclopentenones, we have found that two oxygenated products (4 and 5) are formed when the purification by column chromatography on silica gel takes a long time. The highly functionalized cyclopentenone (4a) obtained as the major product in this manner seems to be an attractive synthon for the synthesis of natural products. For eaxmple, the chiral synthon (1S, 4S)-4-benzyloxycarbonyl-1,4-dihydroxy-2-methoxycarbonyl-3-methyl-2-cyclopentene ((+)-7) with high optical purity was obtained by microbial reduction with Rhodotorula rubra CCY 20-7-1,and the absolute stereochemistry was established independently by using the exciton chirality method and the chemical method.
- 公益社団法人日本薬学会の論文
- 1988-04-25
著者
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末宗 洋
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty Of Pharmaceutical Sciences Kyushu University
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岡野 耕二
Faculty of Pharmaceutical Sciences, Kyushu University
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末宗 洋
九州大学薬学部
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秋田 弘幸
School Of Pharmaceutical Science Toho University
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秋田 弘幸
理化学研究所
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岡野 耕二
Life Science Research Laboratory Japan Tobacco Inc.
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末宗 洋
九州大学大学院薬学府
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水原 由加子
Faculty of Pharmaceutical Sciences, Kyushu University
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秋田 弘幸
The Institute of Physical and Chemical Research (Riken)
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水原 由加子
Faculty Of Pharmaceutical Sciences Kyushu University
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末宗 洋
九州大学大学院薬学研究院
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